CYP94C1 cytochrome P450, family 94, subfamily C, polypeptide 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CYP94C1
Official Full Name: cytochrome P450, family 94, subfamily C, polypeptide 1
Primary source: TAIR:AT2G27690
Locus tag: AT2G27690
See related: Araport:AT2G27690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ''cytochrome P450; cytochrome P450; F15K20.21; F15K20_21; family 94; polypeptide 1; polypeptide 1''; subfamily C
Summary: Encodes a CYP94C1. Has highest omega-hydroxylase activity with 9,10-epoxystearic acid, while also metabolized lauric acid (C12:0) and C18 unsaturated fatty acids. Gene expression is induced in response to wounding and jasmonic acid treatment.
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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we created the double and triple knock-out mutants of three CYP94 genes, CYP94B1, CYP94B3, and CYP94C1. The mutations blocked the oxidation steps and caused JA-Ile to accumulate 3-4-fold the WT levels in the wounded leaves.
Title: Mutations in jasmonoyl-L-isoleucine-12-hydroxylases suppress multiple JA-dependent wound responses in Arabidopsis thaliana.
CYP94B3 and CYP94C1 are responsible for the production of oxidized derivatives of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine in wounded plants.
Title: Sequential oxidation of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine by multiple cytochrome P450 of the CYP94 family through newly identified aldehyde intermediates.
These results highlight the dual function of CYP94B3/C1 in antimicrobial defence.
Title: CYP94-mediated jasmonoyl-isoleucine hormone oxidation shapes jasmonate profiles and attenuates defence responses to Botrytis cinerea infection.
These results identify CYP94B3/C1-mediated oxidation as a major catabolic route for turning over the JA-Ile hormone.
Title: Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover.

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NM_128328.3

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

NP_180337.1

''cytochrome P450, family 94, subfamily C, polypeptide 1'' (CYP94C1); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 94, subfamily B, polypeptide 3 (TAIR:AT3G48520.1); Has 28009 Blast hits to 27927 proteins in 1460 species: Archae - 46; Bacteria - 2607; Metazoa - 10748; Fungi - 6059; Plants - 7560; Viruses - 3; Other Eukaryotes - 986 (source: NCBI BLink).

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