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AAO3 abscisic aldehyde oxidase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817257, updated on 2-Oct-2024

Summary

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Official Symbol
AAO3
Official Full Name
abscisic aldehyde oxidase 3
Primary source
TAIR:AT2G27150
Locus tag
AT2G27150
See related
Araport:AT2G27150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
abscisic aldehyde oxidase 3; ABSCISIC ALDEHYDE OXIDASE 3; Aldehyde oxidase delta; AOdelta; Arabidopsis thaliana aldehyde oxidase 3; At-AO3; AtAAO3; F20F1.2; F20F1_2
Summary
Encodes the aldehyde oxidase delta isoform catalyzing the final step in abscisic acid biosynthesis.
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Genomic context

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See AAO3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Sequence:
Chromosome: 2; NC_003071.7 (11601727..11608450)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene low-molecular-weight cysteine-rich 9 Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes (SMC) family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity. Nurbekova Z, et al. Plant J, 2021 Dec. PMID 34587326
  2. Nitric oxide- induced AtAO3 differentially regulates plant defense and drought tolerance in Arabidopsis thaliana. Khan M, et al. BMC Plant Biol, 2019 Dec 30. PMID 31888479, Free PMC Article
  3. The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves. Seo M, et al. Proc Natl Acad Sci U S A, 2000 Nov 7. PMID 11050171, Free PMC Article
  4. Abscisic aldehyde oxidase in leaves of Arabidopsis thaliana. Seo M, et al. Plant J, 2000 Aug. PMID 10972874
  5. AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal. Nurbekova Z, et al. Plant J, 2024 Oct. PMID 39190782

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal.
    Title: AAO2 impairment enhances aldehyde detoxification by AAO3 in Arabidopsis leaves exposed to UV-C or Rose-Bengal.
  2. Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity.
    Title: Arabidopsis aldehyde oxidase 3, known to oxidize abscisic aldehyde to abscisic acid, protects leaves from aldehyde toxicity.
  3. AtAO3 negatively regulates pathogen-induced salicylic acid pathway, although it is required for drought tolerance, despite the fact that ABA production is not totally dependent on AtAO3.
    Title: Nitric oxide- induced AtAO3 differentially regulates plant defense and drought tolerance in Arabidopsis thaliana.
  4. NAP promotes chlorophyll degradation by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone ABA.
    Title: A NAP-AAO3 regulatory module promotes chlorophyll degradation via ABA biosynthesis in Arabidopsis leaves.
  5. In addition to their aldehyde oxidation activity, AAO1 and AAO3 were found to exhibit NADH oxidase activity, which likewise is associated with the production of superoxide anions.
    Title: Identification of superoxide production by Arabidopsis thaliana aldehyde oxidases AAO1 and AAO3.
  6. AAO3 is overexpressed in ataf1 plants compared to wild-type plants following inoculation with Bgh.
    Title: Transcriptional regulation by an NAC (NAM-ATAF1,2-CUC2) transcription factor attenuates ABA signalling for efficient basal defence towards Blumeria graminis f. sp. hordei in Arabidopsis.
  7. The competence of stomatal guard cells in V. faba to synthesize abscisic acid, using NCED3 and AAO3 from A. thaliana, is reported.
    Title: Transient expression of AtNCED3 and AAO3 genes in guard cells causes stomatal closure in Vicia faba.
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Pathways from PubChem

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General gene information

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NM_001084497.1
NM_001336104.1
NM_001336105.1
NM_001336106.1
NM_001336107.1
NM_128273.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables abscisic aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables indole-3-acetaldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
abscisic aldehyde oxidase 3
NP_001077966.1
  • abscisic aldehyde oxidase 3 (AAO3); CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: aldehyde oxidase 4 (TAIR:AT1G04580.1); Has 18285 Blast hits to 17524 proteins in 1277 species: Archae - 409; Bacteria - 10745; Metazoa - 1018; Fungi - 113; Plants - 280; Viruses - 0; Other Eukaryotes - 5720 (source: NCBI BLink).
NP_180283.1
  • abscisic aldehyde oxidase 3 (AAO3); CONTAINS InterPro DOMAIN/s: Aldehyde oxidase/xanthine dehydrogenase (InterPro:IPR016208), Ferredoxin (InterPro:IPR001041), Molybdopterin dehydrogenase, FAD-binding (InterPro:IPR002346), [2Fe-2S]-binding (InterPro:IPR002888), FAD-binding, type 2 (InterPro:IPR016166), CO dehydrogenase flavoprotein, C-terminal (InterPro:IPR005107), 2Fe-2S ferredoxin, iron-sulphur binding site (InterPro:IPR006058), CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 (InterPro:IPR016169), Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (InterPro:IPR000674), Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding (InterPro:IPR008274); BEST Arabidopsis thaliana protein match is: aldehyde oxidase 4 (TAIR:AT1G04580.1); Has 18285 Blast hits to 17524 proteins in 1277 species: Archae - 409; Bacteria - 10745; Metazoa - 1018; Fungi - 113; Plants - 280; Viruses - 0; Other Eukaryotes - 5720 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11601727..11608450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128273.3 → NP_180283.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64429, Q7G9P4, Q7GD73, Q9SIG7, Q9SLZ2
    UniProtKB/TrEMBL
    A0A178VZD9
    Conserved Domains (6) summary
    PLN00192
    Location:1 → 1331
    PLN00192; aldehyde oxidase
    pfam00941
    Location:223 → 398
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:579 → 689
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:84 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:718 → 1239
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:412 → 520
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

  2. NM_001336104.1 → NP_001324268.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZK7, A0A5S9X1K9

  3. NM_001336105.1 → NP_001324270.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VZD9, A0A1P8AZL6

  4. NM_001336106.1 → NP_001324271.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZL3, A0A5S9X1K9

  5. NM_001084497.1 → NP_001077966.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077966.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64429, Q7G9P4, Q7GD73, Q9SIG7, Q9SLZ2
    UniProtKB/TrEMBL
    A0A178VZD9
    Conserved Domains (6) summary
    PLN00192
    Location:1 → 1331
    PLN00192; aldehyde oxidase
    pfam00941
    Location:223 → 398
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:579 → 689
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:84 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:718 → 1239
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:412 → 520
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

  6. NM_001336107.1 → NP_001324269.1  abscisic aldehyde oxidase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZK7, A0A5S9X1K9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7G9P4.1

Gene LinkOut

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