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TIL2 DNA polymerase epsilon catalytic subunit [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817254, updated on 18-Sep-2024

Summary

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Official Symbol
TIL2
Official Full Name
DNA polymerase epsilon catalytic subunit
Primary source
TAIR:AT2G27120
Locus tag
AT2G27120
See related
Araport:AT2G27120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
POL2B; T20P8.17; T20P8_17; TILTED 2
Summary
Encodes a protein with similarity to DNA polymerase epsilon catalytic subunit. Based on yeast two hybrid analysis, not predicted to be a subunit of the DNA polymerase epsilon complex. No phenotype observed in homozygous mutant embryos or plants but in combination with TIL1-1/til1-1 heterozygotes arrest earlier than til1 homozygotes suggesting TIL2 functions redundantly with TIL1.
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Genomic context

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See TIL2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
49
Sequence:
Chromosome: 2; NC_003071.7 (11581214..11594397)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene C2H2 zinc-finger protein SERRATE (SE) Neighboring gene FAR1-related sequence 3 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene HSP20-like chaperones superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Pedroza-García JA, et al. Plant Physiol, 2017 Mar. PMID 28153919, Free PMC Article
  2. Genetic analysis of two Arabidopsis DNA polymerase epsilon subunits during early embryogenesis. Ronceret A, et al. Plant J, 2005 Oct. PMID 16212602
  3. Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase epsilon. Jenik PD, et al. Plant Cell, 2005 Dec. PMID 16278345, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that the role of Pol epsilon in replicative stress sensing is conserved in plants.
    Title: Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.
  2. role of DNA polymerase epsilon during gametophyte and seed development in A. thaliana, encoded by POL2a and POl2b, with a main regulatory subunit DPB2, is reported
    Title: Genetic analysis of two Arabidopsis DNA polymerase epsilon subunits during early embryogenesis.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of epsilon DNA polymerase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon catalytic subunit
NP_180280.2
  • TILTED 2 (TIL2); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: DNA replication; EXPRESSED IN: leaf whorl, sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT1G08260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11581214..11594397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336102.1 → NP_001325161.1  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2E1, A0A654EWK3

  2. NM_128270.3 → NP_180280.2  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180280.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IFN6, Q9ZVC8
    UniProtKB/TrEMBL
    A0A654EWK3
    Conserved Domains (4) summary
    cd05779
    Location:232 → 436
    DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
    cd05535
    Location:495 → 1114
    POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
    COG0417
    Location:114 → 1125
    PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
    pfam08490
    Location:1475 → 1848
    DUF1744; Domain of unknown function (DUF1744)

  3. NM_001336103.1 → NP_001325160.1  DNA polymerase epsilon catalytic subunit [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2B9, A0A654EWK3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4IFN6.1

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