HO2 heme oxygenase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HO2
Official Full Name: heme oxygenase 2
Primary source: TAIR:AT2G26550
Locus tag: AT2G26550
See related: Araport:AT2G26550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: heme oxygenase 2; T9J22.22; T9J22_22
Summary: Encodes a heme oxygenase-like protein lacking the conserved histidine residue at the active site that is usually involved in heme-iron coordination. It is unable to bind and degrade heme. Mutant analyses suggest a role in photomorphogenesis. The protein can bind the heme precursor, proto IX, which could be biologically significant and point to a role in the regulation of the two tetrapyrrole biosynthetic pathways.
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Genomic context

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See HO2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 7

Sequence:: Chromosome: 2; NC_003071.7 (11291148..11293575, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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NM_128212.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
NOT enables heme binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables heme oxygenase (decyclizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme oxygenase (decyclizing) activity	IEA Inferred from Electronic Annotation more info
enables heme oxygenase (decyclizing) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in heme oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phytochromobilin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: heme oxygenase 2

NP_001189610.1

heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1).

NP_001189611.1

heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1).

NP_180223.2

heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11291148..11293575 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202681.2 → NP_001189610.1 heme oxygenase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48722

UniProtKB/TrEMBL

A0A178VUD0, A0A5S9X1L9, A0A654EXV3

Conserved Domains (1) summary

cd19165
Location:127 → 297

HemeO; heme oxygenase in eukaryotes and some bacteria
NM_001336075.1 → NP_001325234.1 heme oxygenase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B2J8
NM_001202682.1 → NP_001189611.1 heme oxygenase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189611.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9X1L9, A0A654EXV3, F4IUL9

Conserved Domains (1) summary

cd00232
Location:75 → 312

HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...
NM_128212.3 → NP_180223.2 heme oxygenase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180223.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9X1L9, A0A654EXV3, F4IUM0

Conserved Domains (1) summary

cd00232
Location:75 → 352

HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...