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PDE135 Xanthine/uracil permease family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817192, updated on 18-Sep-2024

Summary

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Official Symbol
PDE135
Official Full Name
Xanthine/uracil permease family protein
Primary source
TAIR:AT2G26510
Locus tag
AT2G26510
See related
Araport:AT2G26510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
NAT3; nucleobase ascorbate transporter 3; pigment defective embryo 135; T9J22.18; T9J22_18
Summary
Encodes a plasma-membrane localized nucleobase transporter capable of transporting adenine, guanine, uracil and hypoxanthine. Likely to be a proton-nucleobase symporter.
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Genomic context

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See PDE135 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Sequence:
Chromosome: 2; NC_003071.7 (11273842..11277783)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene cytochrome b6f complex subunit (petM) Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana. Niopek-Witz S, et al. Biochim Biophys Acta, 2014 Dec. PMID 25135661
  2. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
  3. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
  4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001202680.1
NM_128208.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables solute:monoatomic cation symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables uracil transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adenine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within guanine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hypoxanthine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Xanthine/uracil permease family protein
NP_001189609.1
  • pigment defective embryo 135 (PDE135); FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT2G05760.1).
NP_180219.1
  • pigment defective embryo 135 (PDE135); FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT2G34190.1); Has 9126 Blast hits to 9110 proteins in 1899 species: Archae - 65; Bacteria - 7470; Metazoa - 356; Fungi - 126; Plants - 439; Viruses - 1; Other Eukaryotes - 669 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11273842..11277783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336072.1 → NP_001325095.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B238
    Conserved Domains (1) summary
    cl23746
    Location:55 → 409
    Xan_ur_permease; Permease family

  2. NM_128208.5 → NP_180219.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180219.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48718, Q8GZD4
    UniProtKB/TrEMBL
    A0A178VZK9, A0A5S9X1P8
    Conserved Domains (2) summary
    pfam00860
    Location:55 → 461
    Xan_ur_permease; Permease family
    cl23746
    Location:52 → 505
    HCO3_cotransp; HCO3- transporter family

  3. NM_001202680.1 → NP_001189609.1  Xanthine/uracil permease family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4IUL2
    Conserved Domains (1) summary
    cl23746
    Location:52 → 385
    HCO3_cotransp; HCO3- transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GZD4.2

Gene LinkOut

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