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Ctbp2 C-terminal binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81717, updated on 27-Nov-2024

Summary

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Official Symbol
Ctbp2provided by RGD
Official Full Name
C-terminal binding protein 2provided by RGD
Primary source
RGD:68372
See related
EnsemblRapid:ENSRNOG00000017326 AllianceGenome:RGD:68372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including nuclear retinoic acid receptor binding activity; transcription coregulator activity; and transcription corepressor binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in regulation of DNA-templated transcription; synaptic vesicle docking; and white fat cell differentiation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; positive regulation of retinoic acid receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in ribbon synapse. Predicted to be part of transcription repressor complex. Predicted to be active in several cellular components, including photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 135.0), Kidney (RPKM 116.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ctbp2 in Genome Data Viewer
Location:
1q41
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197208536..197348802, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187782064..187918115, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (205001354..205030565, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene ribosomal protein S23, pseudogene 4 Neighboring gene zinc finger RANBP2-type containing 1 Neighboring gene uncharacterized LOC134483950 Neighboring gene small ribosomal subunit protein eS21-like Neighboring gene ATP synthase subunit g, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells. Karaca E, et al. Exp Cell Res, 2015 Mar 1. PMID 25447313
  2. Brn4 promotes the differentiation of radial glial cells into neurons by inhibiting CtBP2. Zhang L, et al. Life Sci, 2020 Aug 1. PMID 31518606
  3. How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release. Maxeiner S, et al. EMBO J, 2016 May 17. PMID 26929012, Free PMC Article
  4. The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway. Han JX, et al. FASEB J, 2022 Sep. PMID 35969153
  5. The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush. Cao X, et al. J Mol Neurosci, 2013 Mar. PMID 23138653

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway.
    Title: The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway.
  2. esults indicated that Brn4 promoted the neuronal differentiation of neural stem cells via inhibition of CtBP2 and is a potential tool for generating neurons in cell replacement therapy of neurodegenerative diseases and brain injury
    Title: Brn4 promotes the differentiation of radial glial cells into neurons by inhibiting CtBP2.
  3. Microenvironmental oxygen levels influence the dimerization and acetylation levels, and thereby the activity, of CtBP2 in proliferating neural stem cells.
    Title: Oxygen-dependent acetylation and dimerization of the corepressor CtBP2 in neural stem cells.
  4. CtBP2 was expressed in normal sciatic nerve. It gradually decreased, reached minimal levels at 7 days after crush, & returned to normal at 4 weeks. It is expressed in Schwann cells & is downregulated during differentiation. It upregulates p75NTR.
    Title: The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of presynaptic active zone structure IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle docking ISO
Inferred from Sequence Orthology
more info
  
involved_in white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in photoreceptor ribbon synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in ribbon synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
C-terminal-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053335.2 → NP_445787.1  C-terminal-binding protein 2

    See identical proteins and their annotated locations for NP_445787.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HX13
    Related
    ENSRNOP00000023404.3, ENSRNOT00000023404.8
    Conserved Domains (2) summary
    COG0111
    Location:593 → 903
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:577 → 895
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    197208536..197348802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275206.1 → XP_063131276.1  C-terminal-binding protein 2 isoform X5

  2. XM_063275168.1 → XP_063131238.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A6HX12

  3. XM_063275150.1 → XP_063131220.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A6HX12

  4. XM_039092148.2 → XP_038948076.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  5. XM_039092175.2 → XP_038948103.1  C-terminal-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AEI5
    Conserved Domains (1) summary
    cd05299
    Location:9 → 327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  6. XM_039092153.2 → XP_038948081.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  7. XM_039092159.2 → XP_038948087.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  8. XM_039092156.2 → XP_038948084.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  9. XM_063275196.1 → XP_063131266.1  C-terminal-binding protein 2 isoform X4

  10. XM_039092165.2 → XP_038948093.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Related
    ENSRNOP00000090411.1, ENSRNOT00000114061.2
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  11. XM_063275191.1 → XP_063131261.1  C-terminal-binding protein 2 isoform X4

  12. XM_063275154.1 → XP_063131224.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A6HX12

  13. XM_039092169.2 → XP_038948097.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A0A8I6AEI5, A6HX12
    Conserved Domains (1) summary
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  14. XM_063275156.1 → XP_063131226.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQH5
    UniProtKB/TrEMBL
    A6HX12

  15. XM_039092139.2 → XP_038948067.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QC65
    Related
    ENSRNOP00000023574.3, ENSRNOT00000023574.8
    Conserved Domains (1) summary
    cd05299
    Location:53 → 371
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  16. XM_039092172.2 → XP_038948100.1  C-terminal-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AEI5, A0A8I6ALN3
    Related
    ENSRNOP00000093562.1, ENSRNOT00000099382.2
    Conserved Domains (1) summary
    cd05299
    Location:21 → 339
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQH5.2 GenPept UniProtKB/Swiss-Prot:Q9EQH5

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