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AUR2 ataurora2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817129, updated on 18-Sep-2024

Summary

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Official Symbol
AUR2
Official Full Name
ataurora2
Primary source
TAIR:AT2G25880
Locus tag
AT2G25880
See related
Araport:AT2G25880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtAUR2; ataurora2; F17H15.9; F17H15_9
Summary
Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle.
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Genomic context

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See AUR2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (11034652..11038191, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene poly(A) polymerase 2 Neighboring gene haloacid dehalogenase-like hydrolase family protein Neighboring gene Oleosin family protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The α-Aurora Kinases Function in Vascular Development in Arabidopsis. Lee KH, et al. Plant Cell Physiol, 2019 Jan 1. PMID 30329113
  2. Arabidopsis α Aurora kinases function in formative cell division plane orientation. Van Damme D, et al. Plant Cell, 2011 Nov. PMID 22045917, Free PMC Article
  3. Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization. Demidov D, et al. Plant J, 2014 Nov. PMID 25146886
  4. Identification and dynamics of two classes of aurora-like kinases in Arabidopsis and other plants. Demidov D, et al. Plant Cell, 2005 Mar. PMID 15722465, Free PMC Article
  5. TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis. Boruc J, et al. Plant Physiol, 2019 Jul. PMID 31097675, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TPX2-LIKE PROTEIN3 Is the Primary Activator of alpha-Aurora Kinases and Is Essential for Embryogenesis.
    Title: TPX2-LIKE PROTEIN3 Is the Primary Activator of α-Aurora Kinases and Is Essential for Embryogenesis.
  2. protein phosphorylation and substrate binding, but not protein dimerization and ubiquitination, are critical for the biological function of AtAUR2.
    Title: The α-Aurora Kinases Function in Vascular Development in Arabidopsis.
  3. Aurora kinases play an essential role in the monitoring of meiosis in plants.
    Title: Altered expression of Aurora kinases in Arabidopsis results in aneu- and polyploidization.
  4. a central role for AUR2 kinase in regulating formative division plane orientation throughout development
    Title: Arabidopsis α Aurora kinases function in formative cell division plane orientation.
  5. Aurora kinase AtAUR2 localized at the nuclear membrane in interphase and located in mitotic spindles during cell division.
    Title: Characterization of plant Aurora kinases during mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001124914.1
NM_001336028.1
NM_128148.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone H3S10 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ataurora2
NP_001118386.1
  • ataurora2 (AUR2); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: ataurora1 (TAIR:AT4G32830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_180159.2
  • ataurora2 (AUR2); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora1 (TAIR:AT4G32830.1); Has 130749 Blast hits to 128519 proteins in 4314 species: Archae - 145; Bacteria - 15305; Metazoa - 47836; Fungi - 12919; Plants - 32506; Viruses - 547; Other Eukaryotes - 21491 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11034652..11038191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336027.1 → NP_001325078.1  ataurora2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B232
    Conserved Domains (1) summary
    cd14007
    Location:85 → 338
    STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase

  2. NM_128148.4 → NP_180159.2  ataurora2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180159.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82309, Q683C9
    UniProtKB/TrEMBL
    A0A178VY38, A0A5S9X177
    Conserved Domains (1) summary
    cd14007
    Location:24 → 277
    STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase

  3. NM_001336028.1 → NP_001325077.1  ataurora2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82309, Q683C9
    UniProtKB/TrEMBL
    A0A1P8B224

  4. NM_001124914.1 → NP_001118386.1  ataurora2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1IKU5, F4ITJ0
    Conserved Domains (2) summary
    smart00220
    Location:25 → 244
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14007
    Location:24 → 245
    STKc_Aurora; Catalytic domain of the Serine/Threonine kinase, Aurora kinase
Nucleotide Protein
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