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ACS4 1-aminocyclopropane-1-carboxylate synthase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816812, updated on 18-Sep-2024

Summary

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Official Symbol
ACS4
Official Full Name
1-aminocyclopropane-1-carboxylate synthase 4
Primary source
TAIR:AT2G22810
Locus tag
AT2G22810
See related
Araport:AT2G22810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE; 1-aminocyclopropane-1-carboxylate synthase 4; 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE POLYPEPTIDE; 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE POLYPEPTIDE; ACC4; ATACS4; T30L20.7
Summary
key regulatory enzyme in the biosynthesis of the plant hormone ethylene. ACS4 is specifically induced by indoleacetic acid (IAA).
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Genomic context

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See ACS4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (9717602..9719594, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Defensin-like (DEFL) family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene squalene epoxidase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ACS4, a primary indoleacetic acid-responsive gene encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis thaliana. Structural characterization, expression in Escherichia coli, and expression characteristics in response to auxin [corrected]. Abel S, et al. J Biol Chem, 1995 Aug 11. PMID 7642574
  2. Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis. Dong Z, et al. Mol Plant, 2016 Jan 4. PMID 26410794
  3. Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis. Prasad ME, et al. Plant Physiol, 2010 Aug. PMID 20511490, Free PMC Article
  4. The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses. Wang NN, et al. J Exp Bot, 2005 Mar. PMID 15699063
  5. The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels. Christians MJ, et al. Plant J, 2009 Jan. PMID 18808454, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results demonstrate that ABA negatively regulates ethylene production through ABI4-mediated transcriptional repression of the ethylene biosynthesis genes ACS4 and ACS8
    Title: Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis.
  2. Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana.
    Title: The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 1-aminocyclopropane-1-carboxylate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ethylene biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ethylene biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to auxin IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
1-aminocyclopropane-1-carboxylate synthase 4
NP_179866.1
  • 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-amino-cyclopropane-1-carboxylate synthase 8 (TAIR:AT4G37770.1); Has 28174 Blast hits to 28171 proteins in 2873 species: Archae - 784; Bacteria - 19102; Metazoa - 651; Fungi - 724; Plants - 1302; Viruses - 0; Other Eukaryotes - 5611 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9717602..9719594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127846.2 → NP_179866.1  1-aminocyclopropane-1-carboxylate synthase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179866.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43309, Q9S9C4
    UniProtKB/TrEMBL
    A0A178VTT6, A0A5S9X0B2
    Conserved Domains (2) summary
    PLN02450
    Location:1 → 473
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
    cl18945
    Location:4 → 147
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q43309.1

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