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NIC1 nicotinamidase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816789, updated on 18-Sep-2024

Summary

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Official Symbol
NIC1
Official Full Name
nicotinamidase 1
Primary source
TAIR:AT2G22570
Locus tag
AT2G22570
See related
Araport:AT2G22570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
A. THALIANA NICOTINAMIDASE 1; ATNIC1; F14M13.1; NIC2; nicotinamidase 1
Summary
encodes a nicotinamidase that converts nicotinamide into nicotinic acid. As such the encoded enzyme is involved in the pyridine nucleotide salvage pathway which may be connected to the de novo NAD biosynthesis through the ABA signaling pathway.
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Genomic context

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See NIC1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Sequence:
Chromosome: 2; NC_003071.7 (9589435..9590932, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene tRNA-Ala Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. Wang G, et al. Plant J, 2007 Mar. PMID 17335512
  2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

General gene information

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NM_127823.3
NM_201782.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nicotinamidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinamidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pyridine nucleotide salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nicotinamidase 1
NP_565539.1
  • nicotinamidase 1 (NIC1); CONTAINS InterPro DOMAIN/s: Isochorismatase-like (InterPro:IPR000868); Has 1180 Blast hits to 1180 proteins in 562 species: Archae - 22; Bacteria - 1075; Metazoa - 0; Fungi - 0; Plants - 49; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).
NP_973511.1
  • nicotinamidase 1 (NIC1); CONTAINS InterPro DOMAIN/s: Isochorismatase-like (InterPro:IPR000868); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9589435..9590932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127823.3 → NP_565539.1  nicotinamidase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565539.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IJK3, Q8LFK8, Q8S8F9, Q9ZQ55
    UniProtKB/TrEMBL
    A0A178VQ19, A0A5S9X084
    Conserved Domains (1) summary
    PLN02743
    Location:3 → 242
    PLN02743; nicotinamidase

  2. NM_201782.3 → NP_973511.1  nicotinamidase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973511.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8S8F9
    Conserved Domains (1) summary
    cl00220
    Location:3 → 157
    cysteine_hydrolases; Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S8F9.1

Gene LinkOut

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