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SR1 signal responsive 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816762, updated on 18-Sep-2024

Summary

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Official Symbol
SR1
Official Full Name
signal responsive 1
Primary source
TAIR:AT2G22300
Locus tag
AT2G22300
See related
Araport:AT2G22300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3; CAMTA3; signal responsive 1; T26C19.4; T26C19_4
Summary
Encodes a putative CAM binding transcription factor. Loss of function mutations show enhanced resistance to fungal and bacterial pathogens suggesting that CAMTA functions to suppress defense responses.
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Genomic context

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See SR1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Sequence:
Chromosome: 2; NC_003071.7 (9471219..9476646)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene RAB GTPase homolog H1D Neighboring gene ubiquitin-specific protease 4 Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity. Prasad KVSK, et al. Cells, 2023 Aug 2. PMID 37566065, Free PMC Article
  2. Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants. Yuan P, et al. Int J Mol Sci, 2022 Feb 16. PMID 35216293, Free PMC Article
  3. Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in Arabidopsis. Galon Y, et al. FEBS Lett, 2008 Mar 19. PMID 18298954
  4. A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana. Jacob F, et al. New Phytol, 2018 Mar. PMID 29226970, Free PMC Article
  5. Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3. Benn G, et al. Proc Natl Acad Sci U S A, 2016 Aug 2. PMID 27432993, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
    Title: CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
  2. DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity.
    Title: DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity.
  3. Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants.
    Title: Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants.
  4. CAMTA-mediated transcriptional regulation defines an early convergence point in NLR- and PRR-mediated signalling.
    Title: A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.
  5. Genetics and pharmacological approaches confirmed the specificity of MEcPP in rapid stress response element (RSRE) induction via the transcription factor CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3 (CAMTA3), in a calcium-dependent manner.
    Title: Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3.
  6. These findings support a model in which DSC1 and DSC2 guard CAMTA3, and they suggest that other negative regulators of immunity may similarly represent guardees.
    Title: Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles.
  7. double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
    Title: Distinct roles for mitogen-activated protein kinase signaling and CALMODULIN-BINDING TRANSCRIPTIONAL ACTIVATOR3 in regulating the peak time and amplitude of the plant general stress response.
  8. CAMTA1, CAMTA2 and CAMTA3 function together to inhibit salicylic acid biosynthesis at warm temperature (22 degrees C).CAMTA1, CAMTA2 and CAMTA3 function together to positively regulate CBF1, CBF2 and CBF3 and freezing tolerance.
    Title: Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis.
  9. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
    Title: SR1, a calmodulin-binding transcription factor, modulates plant defense and ethylene-induced senescence by directly regulating NDR1 and EIN3.
  10. Ca(2+)/Calmodulin-mediated signaling regulates plant response to herbivore attack/wounding by modulating the salicylic acid-jasmonic acid crosstalk through AtSR1.
    Title: Coupling calcium/calmodulin-mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001124889.2
NM_001335795.1
NM_179692.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cold IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extracellular ATP signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of defense response to insect IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
signal responsive 1
NP_001118361.1
  • signal responsive 1 (SR1); FUNCTIONS IN: calmodulin binding, transcription regulator activity; INVOLVED IN: response to biotic stimulus; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Ankyrin repeat-containing domain (InterPro:IPR020683), CG-1 (InterPro:IPR005559), Ankyrin repeat (InterPro:IPR002110), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domains (TAIR:AT5G64220.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_850023.1
  • signal responsive 1 (SR1); FUNCTIONS IN: calmodulin binding, transcription regulator activity; INVOLVED IN: response to biotic stimulus; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Ankyrin repeat-containing domain (InterPro:IPR020683), CG-1 (InterPro:IPR005559), Ankyrin repeat (InterPro:IPR002110), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domains (TAIR:AT5G64220.2); Has 5346 Blast hits to 4463 proteins in 355 species: Archae - 34; Bacteria - 421; Metazoa - 3055; Fungi - 454; Plants - 566; Viruses - 42; Other Eukaryotes - 774 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9471219..9476646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001124889.2 → NP_001118361.1  signal responsive 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WW70, Q8GSA7, Q9FPR9, Q9SID7
    UniProtKB/TrEMBL
    A0A178VUE5
    Conserved Domains (4) summary
    PHA03095
    Location:620 → 746
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:661 → 692
    ANK; ANK repeat [structural motif]
    pfam03859
    Location:23 → 135
    CG-1; CG-1 domain
    cd21759
    Location:857 → 988
    CBD_MYO6-like; calmodulin binding domain found in unconventional myosin-VI and similar proteins

  2. NM_001335795.1 → NP_001325089.1  signal responsive 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VUE5, A0A1P8B262

  3. NM_179692.3 → NP_850023.1  signal responsive 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850023.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WW70, Q8GSA7, Q9FPR9, Q9SID7
    UniProtKB/TrEMBL
    A0A178VUE5
    Conserved Domains (4) summary
    PHA03095
    Location:620 → 746
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:661 → 692
    ANK; ANK repeat [structural motif]
    pfam03859
    Location:23 → 135
    CG-1; CG-1 domain
    cd21759
    Location:857 → 988
    CBD_MYO6-like; calmodulin binding domain found in unconventional myosin-VI and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GSA7.1

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