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ALE2 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816549, updated on 18-Sep-2024

Summary

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Official Symbol
ALE2
Official Full Name
Protein kinase superfamily protein
Primary source
TAIR:AT2G20300
Locus tag
AT2G20300
See related
Araport:AT2G20300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Abnormal Leaf Shape 2; F11A3.15; F11A3_15
Summary
Encodes ABNORMAL LEAF SHAPE 2 (ALE2), a receptor-like protein kinase (RLK) with a cluster of basic amino acid residues followed by a cysteine-containing sequence in the putative extracellular domain. Function together with ACR4 (Arabidopsis homolog of the Crinkly4) and ALE1 in positively regulating protoderm-specific gene expression and for the formation of leafy organs. ale2 mutants have various epidermal defects, including disorganization of epidermis-related tissues, defects in the leaf cuticle and the fusion of organs.
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Genomic context

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See ALE2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (8755852..8760298, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene myosin-like protein XIG Neighboring gene miscRNA Neighboring gene RPM1 interacting protein 13 Neighboring gene DENN (AEX-3) domain-containing protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel receptor-like kinase ALE2 controls shoot development by specifying epidermis in Arabidopsis. Tanaka H, et al. Development, 2007 May. PMID 17376810
  2. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822
  3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_179667.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within plant epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant organ formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
acts_upstream_of_or_within protoderm histogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Protein kinase superfamily protein
NP_849998.1
  • Abnormal Leaf Shape 2 (ALE2); FUNCTIONS IN: kinase activity; INVOLVED IN: shoot development, organ formation, protoderm histogenesis, cuticle development; LOCATED IN: plasma membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G56890.1); Has 119232 Blast hits to 117654 proteins in 4402 species: Archae - 117; Bacteria - 14202; Metazoa - 43938; Fungi - 9729; Plants - 33678; Viruses - 349; Other Eukaryotes - 17219 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    8755852..8760298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179667.3 → NP_849998.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RWW0, Q9SK72
    UniProtKB/TrEMBL
    A0A178VTE9, A0A5S9WZR7, A0A654EVQ1
    Conserved Domains (1) summary
    cd14066
    Location:355 → 619
    STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RWW0.1

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