U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AMS basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816194, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
AMS
Official Full Name
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
Primary source
TAIR:AT2G16910
Locus tag
AT2G16910
See related
Araport:AT2G16910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ABORTED MICROSPORES; F12A24.9; F12A24_9
Summary
Encodes a basic helix-loop helix transcription factor involved in tapetal cell development. Loss of function mutations are male sterile. AMS binds to a region termed the E box of target gene promoters.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AMS in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (7331721..7334254)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin-conjugating enzyme 23 Neighboring gene Ribosomal protein L27 family protein Neighboring gene Splicing factor, CC1-like protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis. Ferguson AC, et al. New Phytol, 2017 Jan. PMID 27787905, Free PMC Article
  2. AMS-dependent and independent regulation of anther transcriptome and comparison with those affected by other Arabidopsis anther genes. Ma X, et al. BMC Plant Biol, 2012 Feb 15. PMID 22336428, Free PMC Article
  3. The Regulation of Sporopollenin Biosynthesis Genes for Rapid Pollen Wall Formation. Wang K, et al. Plant Physiol, 2018 Sep. PMID 30018171, Free PMC Article
  4. The tapetal AHL family protein TEK determines nexine formation in the pollen wall. Lou Y, et al. Nat Commun, 2014 May 8. PMID 24804694, Free PMC Article
  5. The ABORTED MICROSPORES regulatory network is required for postmeiotic male reproductive development in Arabidopsis thaliana. Xu J, et al. Plant Cell, 2010 Jan. PMID 20118226, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The TDF1-AMS complex acts in concert to activate EXPB5 expression through a feed-forward loop. The identification of the regulatory pathway between TDF1 and AMS provides an interlocked feed-forward loop circuit that precisely regulates the transcriptional cascades that support anther development.
    Title: Positive regulation of AMS by TDF1 and the formation of a TDF1-AMS complex are required for anther development in Arabidopsis thaliana.
  2. AMS may competitively form a protein complex with other tapetum-expressed transcription factors, and that biphasic regulation is due to repression of upstream regulators and promotion of AMS protein degradation.
    Title: Biphasic regulation of the transcription factor ABORTED MICROSPORES (AMS) is essential for tapetum and pollen development in Arabidopsis.
  3. AMS mutation affects genes with putative functions in phosphorylation, exocytosis, stress-response and ubiquitin-proteasome pathways during male reproduction.
    Title: AMS-dependent and independent regulation of anther transcriptome and comparison with those affected by other Arabidopsis anther genes.
  4. DYT1, TDF1 and AMS function in early tapetum development, while MS188 and MS1 are important for late tapetum development.
    Title: A genetic pathway for tapetum development and function in Arabidopsis.
  5. AMS alters the expression of genes required for tapetal differentiation and degradation.
    Title: The ABORTED MICROSPORES regulatory network is required for postmeiotic male reproductive development in Arabidopsis thaliana.
  6. AMS can target ASHR3 to chromatin and regulate genes involved in stamen development and function
    Title: The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED MICROSPORES (AMS).
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_127244.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anther wall tapetum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NP_179283.2
  • ABORTED MICROSPORES (AMS); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: tapetal layer development, regulation of transcription, pollen development; LOCATED IN: nucleus; EXPRESSED IN: petal, leaf whorl, sepal, flower, seed; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G26744.4); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    7331721..7334254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127244.4 → NP_179283.2  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179283.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZVX2
    UniProtKB/TrEMBL
    A0A5S9WYU3, A0A654EV10
    Conserved Domains (2) summary
    cd11443
    Location:313 → 384
    bHLH_AtAMS_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein aborted microspores (AMS) and similar proteins
    pfam14215
    Location:8 → 148
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZVX2.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools