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OTP51 endonuclease [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816078, updated on 18-Sep-2024

Summary

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Official Symbol
OTP51
Official Full Name
endonuclease
Primary source
TAIR:AT2G15820
Locus tag
AT2G15820
See related
Araport:AT2G15820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19G14.18; F19G14_18; ORGANELLE TRANSCRIPT PROCESSING 51
Summary
Encodes a protein that promotes splicing of type II introns. otp51 mutants fail to splice intron 2 of plastid ycf3 transcripts, a factor required for the assembly of Photosystem I. Therefore, homozygous otp51 mutants have profound photosynthetic defects and can only survive in sucrose-supplemented in vitro cultures under low light conditions. OTP51 may also be involved in splicing several other transcripts and precursor forms of the trnL, trnG, trnI, and trnA transcripts also accumulate in otp51 mutants. Although OTP51 shares some homology with DNA endonucleases, it lacks key catalytic residues suggesting that it does not participate in DNA cleavage.
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Genomic context

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See OTP51 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_003071.7 (6888540..6891409, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The pentatricopeptide repeat gene OTP51 with two LAGLIDADG motifs is required for the cis-splicing of plastid ycf3 intron 2 in Arabidopsis thaliana. de Longevialle AF, et al. Plant J, 2008 Oct. PMID 18557832
  2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OTP51 is an organelle splicing factor required for splicing of plastid ycf3 intron 2, a photosystem I assembly protein.
    Title: The pentatricopeptide repeat gene OTP51 with two LAGLIDADG motifs is required for the cis-splicing of plastid ycf3 intron 2 in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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NM_127144.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Group II intron splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chloroplast mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photosystem I assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
endonuclease
NP_565382.4
  • ORGANELLE TRANSCRIPT PROCESSING 51 (OTP51); FUNCTIONS IN: endonuclease activity; INVOLVED IN: photosystem I assembly, nuclear mRNA cis splicing, via spliceosome, Group II intron splicing; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885), LAGLIDADG DNA endonuclease (InterPro:IPR004860); BEST Arabidopsis thaliana protein match is: Pentatricopeptide repeat (PPR) superfamily protein (TAIR:AT5G61990.1); Has 8373 Blast hits to 4744 proteins in 190 species: Archae - 0; Bacteria - 4; Metazoa - 37; Fungi - 65; Plants - 8172; Viruses - 0; Other Eukaryotes - 95 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    6888540..6891409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127144.7 → NP_565382.4  endonuclease [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565382.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WM50, Q93ZT4, Q9XIL5
    UniProtKB/TrEMBL
    A0A5S9WYB7, A0A654ET70
    Conserved Domains (4) summary
    COG0457
    Location:375 → 555
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00004
    Location:464 → 490
    PPR; PPR repeat [structural motif]
    pfam03161
    Location:648 → 795
    LAGLIDADG_2; LAGLIDADG DNA endonuclease family
    pfam13041
    Location:533 → 576
    PPR_2; PPR repeat family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XIL5.3

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