U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NRPB3 DNA-directed RNA polymerase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816035, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
NRPB3
Official Full Name
DNA-directed RNA polymerase family protein
Primary source
TAIR:AT2G15430
Locus tag
AT2G15430
See related
Araport:AT2G15430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F26H6.5; F26H6_5; NRPD3; NRPE3A; RBP36A; RPB35.5A
Summary
Non-catalytic subunit of nuclear DNA-dependent RNA polymerases II, IV and V; homologous to budding yeast RPB3 and the E. coli RNA polymerase alpha subunit. A closely related paralog, encoded by At2g15400, can substitute for At2g15430 in the context of Pol V.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NRPB3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (6733534..6735819)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene myosin heavy chain-like protein Neighboring gene ncRNA Neighboring gene polysaccharide biosynthesis protein (DUF579)

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Chen L, et al. Development, 2016 May 1. PMID 26989174, Free PMC Article
  2. Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses. Fukudome A, et al. Plant J, 2014 Oct. PMID 25041272
  3. Association between 36- and 13.6-kDa alpha-like subunits of Arabidopsis thaliana RNA polymerase II. Ulmasov T, et al. J Biol Chem, 1996 Mar 1. PMID 8617787
  4. DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV. Zhang H, et al. Proc Natl Acad Sci U S A, 2013 May 14. PMID 23637343, Free PMC Article
  5. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Law JA, et al. Curr Biol, 2010 May 25. PMID 20409711, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

NM_001335452.1
NM_127103.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stomatal complex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stomatal complex patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase IV complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase V complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA-directed RNA polymerase family protein
NP_179145.1
  • NRPB3; FUNCTIONS IN: DNA-directed RNA polymerase activity, protein dimerization activity, DNA binding; INVOLVED IN: transcription; LOCATED IN: in 6 components; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, insert domain (InterPro:IPR011262), DNA-directed RNA polymerase, dimerisation (InterPro:IPR011261), DNA-directed RNA polymerase, RpoA/D/Rpb3-type (InterPro:IPR011263), DNA-directed RNA polymerase, 30-40kDa subunit, conserved site (InterPro:IPR001514), DNA-directed RNA polymerase, RBP11-like (InterPro:IPR009025); BEST Arabidopsis thaliana protein match is: DNA-directed RNA polymerase family protein (TAIR:AT2G15400.1); Has 1362 Blast hits to 1362 proteins in 353 species: Archae - 243; Bacteria - 1; Metazoa - 278; Fungi - 347; Plants - 109; Viruses - 0; Other Eukaryotes - 384 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    6733534..6735819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001335451.1 → NP_001324802.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B178

  2. NM_127103.3 → NP_179145.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39211
    UniProtKB/TrEMBL
    A0A178W202, A0A5S9WYB6, Q8LAJ1
    Conserved Domains (1) summary
    cd07031
    Location:10 → 302
    RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II

  3. NM_001335452.1 → NP_001324803.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B195
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39211.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools