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TIC21 translocon at inner membrane of chloroplasts 21 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816018, updated on 18-Sep-2024

Summary

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Official Symbol
TIC21
Official Full Name
translocon at inner membrane of chloroplasts 21
Primary source
TAIR:AT2G15290
Locus tag
AT2G15290
See related
Araport:AT2G15290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTic21; ATTIC21; CHLOROPLAST IMPORT APPARATUS 5; CIA5; F27O10.6; F27O10_6; PERMEASE IN CHLOROPLASTS 1; PIC1; translocon at inner membrane of chloroplasts 21; TRANSLOCON AT INNER MEMBRANE OF CHLOROPLASTS 21
Summary
Encodes a protein located in the chloroplast inner envelope. The study of mutant defective in the gene product suggests that the protein is involved in the translocation of protein across the envelope membrane into the chloroplast stroma.
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Genomic context

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See TIC21 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (6642300..6644055, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PRKR-interacting protein Neighboring gene miscRNA Neighboring gene Reticulon family protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron. Duy D, et al. Plant Physiol, 2011 Apr. PMID 21343424, Free PMC Article
  2. A 1-megadalton translocation complex containing Tic20 and Tic21 mediates chloroplast protein import at the inner envelope membrane. Kikuchi S, et al. Plant Cell, 2009 Jun. PMID 19531596, Free PMC Article
  3. Tic21 is an essential translocon component for protein translocation across the chloroplast inner envelope membrane. Teng YS, et al. Plant Cell, 2006 Sep. PMID 16891400, Free PMC Article
  4. PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport. Duy D, et al. Plant Cell, 2007 Mar. PMID 17337631, Free PMC Article
  5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By mediating iron uptake and sequestering processes in plastids, PIC1 is crucial for plant growth and development in general and in particular for fruit maturation.
    Title: The chloroplast permease PIC1 regulates plant growth and development by directing homeostasis and transport of iron.
  2. PIC1 functions in iron transport across the inner envelope of chloroplasts and hence in cellular metal homeostasis. [PIC1] [PERMEASE INCHLOROPLASTS1]
    Title: PIC1, an ancient permease in Arabidopsis chloroplasts, mediates iron transport.
  3. Tic21 functions as part of the inner membrane protein-conducting channel and may be more important for later stages of leaf development. [Tic21] [CIA5]
    Title: Tic21 is an essential translocon component for protein translocation across the chloroplast inner envelope membrane.
Submit: New GeneRIF Correction

General gene information

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NM_127089.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables iron ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein import into chloroplast stroma IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Tic complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Tic complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
translocon at inner membrane of chloroplasts 21
NP_565372.1
  • translocon at inner membrane of chloroplasts 21 (TIC21); FUNCTIONS IN: copper uptake transmembrane transporter activity, protein homodimerization activity, iron ion transmembrane transporter activity; INVOLVED IN: protein import into chloroplast stroma, cellular metal ion homeostasis; LOCATED IN: chloroplast, chloroplast inner membrane, chloroplast envelope, Tic complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3611 (InterPro:IPR022051); Has 312 Blast hits to 312 proteins in 84 species: Archae - 0; Bacteria - 154; Metazoa - 0; Fungi - 0; Plants - 61; Viruses - 0; Other Eukaryotes - 97 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    6642300..6644055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127089.4 → NP_565372.1  translocon at inner membrane of chloroplasts 21 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565372.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SHU7
    UniProtKB/TrEMBL
    A0A654ET01, A0A7G2E8I6
    Conserved Domains (1) summary
    pfam12263
    Location:107 → 282
    DUF3611; Protein of unknown function (DUF3611)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SHU7.1

Gene LinkOut

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