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AGT alanine:glyoxylate aminotransferase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815822, updated on 18-Sep-2024

Summary

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Official Symbol
AGT
Official Full Name
alanine:glyoxylate aminotransferase
Primary source
TAIR:AT2G13360
Locus tag
AT2G13360
See related
Araport:AT2G13360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AGT1; alanine:glyoxylate aminotransferase; ALANINE:GLYOXYLATE AMINOTRANSFERASE; ALANINE:GLYOXYLATE AMINOTRANSFERASE 1; F14O4.7; F14O4_7; L-serine:glyoxylate aminotransferase; SGAT
Summary
Encodes a peroxisomal photorespiratory enzyme that catalyzes transamination reactions with multiple substrates. It is involved in photorespiration.
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Genomic context

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See AGT in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Sequence:
Chromosome: 2; NC_003071.7 (5538740..5541479, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene chromatin remodeling 5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Arabidopsis serine:glyoxylate aminotransferase, AGT1, as an asparagine aminotransferase. Zhang Q, et al. Phytochemistry, 2013 Jan. PMID 23098902
  2. Peroxisomal alanine : glyoxylate aminotransferase (AGT1) is a photorespiratory enzyme with multiple substrates in Arabidopsis thaliana. Liepman AH, et al. Plant J, 2001 Mar. PMID 11309139
  3. Identification and characterization of omega-amidase as an enzyme metabolically linked to asparagine transamination in Arabidopsis. Zhang Q, et al. Phytochemistry, 2014 Mar. PMID 24461228
  4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
  5. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the enzyme serine:glyoxylate aminotransferase encoded by AGT1 has been identified as an asparagine aminotransferase in Arabidopsis
    Title: Identification and characterization of omega-amidase as an enzyme metabolically linked to asparagine transamination in Arabidopsis.
  2. The results suggest that AGT1 is involved in Asn metabolism in Arabidopsis.
    Title: Characterization of Arabidopsis serine:glyoxylate aminotransferase, AGT1, as an asparagine aminotransferase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001335388.1
NM_126925.5
NM_179620.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables L-serine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine-pyruvate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within photorespiration NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
alanine:glyoxylate aminotransferase
NP_001318216.1
  • alanine:glyoxylate aminotransferase (AGT); FUNCTIONS IN: serine-pyruvate transaminase activity, serine-glyoxylate transaminase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class V/Cysteine desulfurase (InterPro:IPR000192), Aminotransferase class-V pyridoxal-phosphate binding site (InterPro:IPR020578), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); Has 6407 Blast hits to 6405 proteins in 1610 species: Archae - 309; Bacteria - 3905; Metazoa - 186; Fungi - 125; Plants - 148; Viruses - 0; Other Eukaryotes - 1734 (source: NCBI BLink).
NP_849951.1
  • alanine:glyoxylate aminotransferase (AGT); FUNCTIONS IN: serine-pyruvate transaminase activity, serine-glyoxylate transaminase activity, alanine-glyoxylate transaminase activity; INVOLVED IN: photorespiration; LOCATED IN: apoplast, peroxisome, plasma membrane, chloroplast, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class V/Cysteine desulfurase (InterPro:IPR000192), Aminotransferase class-V pyridoxal-phosphate binding site (InterPro:IPR020578), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); Has 6407 Blast hits to 6405 proteins in 1610 species: Archae - 309; Bacteria - 3905; Metazoa - 186; Fungi - 125; Plants - 148; Viruses - 0; Other Eukaryotes - 1734 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    5538740..5541479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001335388.1 → NP_001318216.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81248, Q56YA5
    UniProtKB/TrEMBL
    A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
    Conserved Domains (1) summary
    PLN02409
    Location:1 → 401
    PLN02409; serine--glyoxylate aminotransaminase

  2. NM_126925.5 → NP_178969.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81248, Q56YA5
    UniProtKB/TrEMBL
    A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
    Conserved Domains (1) summary
    PLN02409
    Location:1 → 401
    PLN02409; serine--glyoxylate aminotransaminase

  3. NM_179620.2 → NP_849951.1  alanine:glyoxylate aminotransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81248, Q56YA5
    UniProtKB/TrEMBL
    A0A178VX39, A0A5S9XHQ3, A0A7G2EC25
    Conserved Domains (1) summary
    PLN02409
    Location:1 → 401
    PLN02409; serine--glyoxylate aminotransaminase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56YA5.2

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