Sgpp1 sphingosine-1-phosphate phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sgpp1provided by RGD
Official Full Name: sphingosine-1-phosphate phosphatase 1provided by RGD
Primary source: RGD:727829
See related: EnsemblRapid:ENSRNOG00000005175 AllianceGenome:RGD:727829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spp1
Summary: Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in several processes, including ER to Golgi ceramide transport; phospholipid dephosphorylation; and sphingosine metabolic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway; and sphinganine-1-phosphate metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 255.4), Spleen (RPKM 119.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (100161024..100182214, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (94425339..94446534, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (98675324..98696492, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d6rat164 (e-PCR)
- UniSTS:122228

Sgpp1 (e-PCR), detects polymorphism
- UniSTS:496530

AI229520 (e-PCR)
- UniSTS:261808

RH136984 (e-PCR)
- UniSTS:219073

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dihydrosphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	IEA Inferred from Electronic Annotation more info
involved_in ER to Golgi ceramide transport	ISO Inferred from Sequence Orthology more info
involved_in ER to Golgi ceramide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermis development	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermis development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphinganine-1-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphinganine-1-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingosine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
NOT located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sphingosine-1-phosphate phosphatase 1

Names: SPPase1; sphingosine-1-phosphatase 1; sphingosine-1-phosphate phosphohydrolase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030874.2 → NP_110501.2 sphingosine-1-phosphate phosphatase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q99P55

UniProtKB/TrEMBL

A6HC84, F1LPB0

Related

ENSRNOP00000006913.7, ENSRNOT00000006913.8

Conserved Domains (1) summary

cd03388
Location:117 → 264

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...