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ACO3 aconitase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815120, updated on 18-Sep-2024

Summary

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Official Symbol
ACO3
Official Full Name
aconitase 3
Primary source
TAIR:AT2G05710
Locus tag
AT2G05710
See related
Araport:AT2G05710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
aconitase 3; T3P4.5; T3P4_5
Summary
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. ACO3 is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
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Genomic context

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See ACO3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Sequence:
Chromosome: 2; NC_003071.7 (2141329..2146678)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response. Pascual J, et al. Plant Physiol, 2021 Aug 3. PMID 34618107, Free PMC Article
  2. Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis. Hooks MA, et al. Biochem J, 2014 Oct 15. PMID 25061985
  3. Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana. Moeder W, et al. Plant Mol Biol, 2007 Jan. PMID 17013749
  4. The iron-responsive element (IRE)/iron-regulatory protein 1 (IRP1)-cytosolic aconitase iron-regulatory switch does not operate in plants. Arnaud N, et al. Biochem J, 2007 Aug 1. PMID 17437406, Free PMC Article
  5. Protein phosphatase 2A (PP2A) regulatory subunit B'γ interacts with cytoplasmic ACONITASE 3 and modulates the abundance of AOX1A and AOX1D in Arabidopsis thaliana. Konert G, et al. New Phytol, 2015 Feb. PMID 25307043

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response.
    Title: ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response.
  2. PP2A-B'gamma physically interacts with the cytoplasmic form of aconitase and PP2A-B'gamma impacts reactive oxygen species homeostasis by controlling the abundance of specific alternative oxidase isoforms, AOX1A and AOX1D, in leaf mitochondria.
    Title: Protein phosphatase 2A (PP2A) regulatory subunit B'γ interacts with cytoplasmic ACONITASE 3 and modulates the abundance of AOX1A and AOX1D in Arabidopsis thaliana.
  3. The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins.
    Title: The iron-responsive element (IRE)/iron-regulatory protein 1 (IRP1)-cytosolic aconitase iron-regulatory switch does not operate in plants.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_126589.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables aconitate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables copper ion binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within citrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in citrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within isocitrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in seedling development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type cell wall HDA PubMed 
located_in plant-type vacuole HDA PubMed 

General protein information

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Preferred Names
aconitase 3
NP_178634.2
  • aconitase 3 (ACO3); FUNCTIONS IN: aconitate hydratase activity, copper ion binding, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, mitochondrion, cell wall, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase-like core (InterPro:IPR015937), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 1 (TAIR:AT4G35830.1); Has 20552 Blast hits to 20369 proteins in 2575 species: Archae - 558; Bacteria - 10777; Metazoa - 503; Fungi - 660; Plants - 232; Viruses - 0; Other Eukaryotes - 7822 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    2141329..2146678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126589.3 → NP_178634.2  aconitase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178634.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L784, Q9SIB9
    UniProtKB/TrEMBL
    A0A178VV24, A0A5S9WXC8
    Conserved Domains (1) summary
    PLN00070
    Location:59 → 990
    PLN00070; aconitate hydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SIB9.2

Gene LinkOut

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