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SPP signal peptide peptidase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814841, updated on 18-Sep-2024

Summary

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Official Symbol
SPP
Official Full Name
signal peptide peptidase
Primary source
TAIR:AT2G03120
Locus tag
AT2G03120
See related
Araport:AT2G03120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSPP; signal peptide peptidase; T18E12.21; T18E12_21
Summary
homologous to Signal Peptide Peptidases (SPP), required for pollen development and pollen germination. No homozygotes could be recovered from a T-DNA insertion mutant.
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Genomic context

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See SPP in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Sequence:
Chromosome: 2; NC_003071.7 (937383..940551)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative RNA-binding protein Neighboring gene Ribosomal protein L12/ ATP-dependent Clp protease adaptor protein ClpS family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The signal peptide peptidase is required for pollen function in Arabidopsis. Han S, et al. Plant Physiol, 2009 Mar. PMID 19168645, Free PMC Article
  2. Signal peptide peptidase and its homologs in Arabidopsis thaliana--plant tissue-specific expression and distinct subcellular localization. Tamura T, et al. FEBS J, 2008 Jan. PMID 18067581
  3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
  5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_126363.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
signal peptide peptidase
NP_565294.1
  • signal peptide peptidase (SPP); FUNCTIONS IN: aspartic-type endopeptidase activity; INVOLVED IN: pollen germination, pollen development; LOCATED IN: endoplasmic reticulum, endoplasmic reticulum membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase A22, presenilin signal peptide (InterPro:IPR006639), Peptidase A22B, signal peptide peptidase (InterPro:IPR007369); BEST Arabidopsis thaliana protein match is: SIGNAL PEPTIDE PEPTIDASE-LIKE 1 (TAIR:AT4G33410.1); Has 989 Blast hits to 959 proteins in 196 species: Archae - 4; Bacteria - 0; Metazoa - 468; Fungi - 136; Plants - 243; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    937383..940551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126363.7 → NP_565294.1  signal peptide peptidase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565294.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81062, Q8LAP9
    UniProtKB/TrEMBL
    A0A178VY21, A0A5S9WWS1
    Conserved Domains (1) summary
    pfam04258
    Location:47 → 323
    Peptidase_A22B; Signal peptide peptidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81062.1

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