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AL6 alfin-like 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814776, updated on 18-Sep-2024

Summary

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Official Symbol
AL6
Official Full Name
alfin-like 6
Primary source
TAIR:AT2G02470
Locus tag
AT2G02470
See related
Araport:AT2G02470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
alfin-like 6; T16F16.26; T16F16_26
Summary
Encodes a member of the Alfin1-like family of nuclear-localized PHD (plant homeodomain) domain containing proteins that acts as a novel upstream regulator of root hair formation during Pi starvation. All AL proteins except AL3 bind to di- or trimethylated histone H3 (H3K4me3/2). Members of this family include: AT5G05610 (AL1), AT3G11200 (AL2), AT3G42790 (AL3), AT5G26210 (AL4), AT5G20510 (AL5), AT2G02470 (AL6), AT1G14510 (AL7).
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Genomic context

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See AL6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Sequence:
Chromosome: 2; NC_003071.7 (652564..654985)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NAC domain containing protein 35 Neighboring gene AAA-type ATPase family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling. Vélez-Bermúdez IC, et al. BMC Genomics, 2021 Nov 22. PMID 34809577, Free PMC Article
  2. A PHD in histone language: on the role of histone methylation in plant responses to phosphate deficiency. Chandrika NN, et al. Plant Signal Behav, 2013 Jun. PMID 23531693, Free PMC Article
  3. ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis. Chandrika NNP, et al. New Phytol, 2013 May. PMID 23432399
  4. The Alfin-like homeodomain finger protein AL5 suppresses multiple negative factors to confer abiotic stress tolerance in Arabidopsis. Wei W, et al. Plant J, 2015 Mar. PMID 25619813
  5. Arabidopsis AL PHD-PRC1 complexes promote seed germination through H3K4me3-to-H3K27me3 chromatin state switch in repression of seed developmental genes. Molitor AM, et al. PLoS Genet, 2014 Jan. PMID 24465219, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling.
    Title: Chromatin enrichment for proteomics in plants (ChEP-P) implicates the histone reader ALFIN-LIKE 6 in jasmonate signalling.
  2. AL6 contains a plant homeo domain finger that can bind to trimethylated lysine 4 of histone H3
    Title: A PHD in histone language: on the role of histone methylation in plant responses to phosphate deficiency.
  3. we propose that AL PHD-PRC1 complexes(AL6 and AL7 ), built around H3K4me3, lead to a switch from the H3K4me3-associated active to the H3K27me3-associated repressive transcription state of seed developmental genes during seed germination.
    Title: Arabidopsis AL PHD-PRC1 complexes promote seed germination through H3K4me3-to-H3K27me3 chromatin state switch in repression of seed developmental genes.
  4. AL6 controls the transcription of a suite of genes critical for root hair elongation under low phosphate conditions.
    Title: ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001202573.2
NM_001335119.1
NM_126302.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within root hair elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
alfin-like 6
NP_001189502.1
  • alfin-like 6 (AL6); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 7 (TAIR:AT1G14510.1).
NP_178351.1
  • alfin-like 6 (AL6); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 7 (TAIR:AT1G14510.1); Has 1820 Blast hits to 1777 proteins in 193 species: Archae - 0; Bacteria - 0; Metazoa - 798; Fungi - 350; Plants - 563; Viruses - 0; Other Eukaryotes - 109 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    652564..654985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202573.2 → NP_001189502.1  alfin-like 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VSB3, A0A5S9WWM8, A0A654ERA8
    Conserved Domains (2) summary
    cd15613
    Location:194 → 243
    PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
    pfam12165
    Location:12 → 139
    Alfin

  2. NM_001335119.1 → NP_001323925.1  alfin-like 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AYM4

  3. NM_126302.3 → NP_178351.1  alfin-like 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178351.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IQE0, Q8LAH0, Q8S8M9
    UniProtKB/TrEMBL
    A0A178VQJ7, A0A5S9WWM8, A0A654ERA8
    Conserved Domains (2) summary
    cd15613
    Location:203 → 252
    PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
    pfam12165
    Location:12 → 139
    Alfin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S8M9.1

Gene LinkOut

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