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Ica1 islet cell autoantigen 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81024, updated on 27-Nov-2024

Summary

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Official Symbol
Ica1provided by RGD
Official Full Name
islet cell autoantigen 1provided by RGD
Primary source
RGD:621465
See related
EnsemblRapid:ENSRNOG00000008628 AllianceGenome:RGD:621465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ica69
Summary
Enables protein domain specific binding activity. Involved in regulation of protein-containing complex assembly. Located in Golgi apparatus; dendrite; and perinuclear region of cytoplasm. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 276.6), Brain (RPKM 138.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ica1 in Genome Data Viewer
Location:
4q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (37622759..37771055, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (36656475..36804705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (34635509..34780187, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486727 Neighboring gene glucocorticoid induced 1 Neighboring gene replication protein A3 Neighboring gene uncharacterized LOC102550643 Neighboring gene neurexophilin 1 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Metabolic and genomic dissection of diabetes in the Cohen rat. Yagil C, et al. Physiol Genomics, 2007 Apr 24. PMID 17213368
  2. Reduced thymic expression of islet antigen contributes to loss of self-tolerance. Mathews CE, et al. Ann N Y Acad Sci, 2003 Nov. PMID 14679103
  3. HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus. Roep BO, et al. Eur J Immunol, 1996 Jun. PMID 8647206
  4. PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites. Xu J, et al. J Neurosci, 2014 Nov 12. PMID 25392508, Free PMC Article
  5. Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes. Barkalifa R, et al. Physiol Genomics, 2010 Aug. PMID 20530722

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study showed that PICK1, being negatively regulated by ICA69, could facilitate synapse maturation.
    Title: PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.
  2. Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
    Title: Sex-specific genetic dissection of diabetes in a rodent model identifies Ica1 and Ndufa4 as major candidate genes.
  3. Islet cell autoantigen 69 kDa (ICA69) regulates AMPA receptor trafficking by preventing formation of homomeric protein interacting with C kinase 1 (PICK1) Bin/amphiphysin/Rvs (BAR) domain complexes.
    Title: PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors.
  4. ICA69 is an arfaptin-related protein that is likely to play a role in membrane trafficking at the Golgi complex and immature secretory granules in neurosecretory cells
    Title: Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
  5. Ica1, on chromosome 4, is a high priority candidate gene for the development of diet-induced diabetes in the Cohen rat.
    Title: Metabolic and genomic dissection of diabetes in the Cohen rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables membrane curvature sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane curvature sensor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
islet cell autoantigen 1
Names
69 kDa islet cell autoantigen
ICAp69
islet cell autoantigen 1, 69 kDa
islet cell autoantigen p69
p69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030844.2 → NP_110471.2  islet cell autoantigen 1

    See identical proteins and their annotated locations for NP_110471.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078812
    UniProtKB/Swiss-Prot
    Q63054, Q6P3W0
    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:260 → 480
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    37622759..37771055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236095.5 → XP_006236157.1  islet cell autoantigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006236157.1

    UniProtKB/Swiss-Prot
    Q63054, Q6P3W0
    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:260 → 480
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

  2. XM_039108416.2 → XP_038964344.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7, F7FFT7
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:261 → 459
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

  3. XM_063286740.1 → XP_063142810.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7

  4. XM_063286738.1 → XP_063142808.1  islet cell autoantigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05

  5. XM_063286742.1 → XP_063142812.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7

  6. XM_006236094.5 → XP_006236156.1  islet cell autoantigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006236156.1

    UniProtKB/Swiss-Prot
    Q63054, Q6P3W0
    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05
    Related
    ENSRNOP00000095862.1, ENSRNOT00000118007.2
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:260 → 480
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

  7. XM_063286741.1 → XP_063142811.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7

  8. XM_063286739.1 → XP_063142809.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7

  9. XM_006236092.5 → XP_006236154.1  islet cell autoantigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006236154.1

    UniProtKB/Swiss-Prot
    Q63054, Q6P3W0
    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:260 → 480
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

  10. XM_006236093.5 → XP_006236155.1  islet cell autoantigen 1 isoform X1

    See identical proteins and their annotated locations for XP_006236155.1

    UniProtKB/Swiss-Prot
    Q63054, Q6P3W0
    UniProtKB/TrEMBL
    A0A0G2K9Z2, A6IDX8, Q6AZ05
    Related
    ENSRNOP00000075191.1, ENSRNOT00000077329.3
    Conserved Domains (2) summary
    cd07661
    Location:52 → 255
    BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
    pfam04629
    Location:260 → 480
    ICA69; Islet cell autoantigen ICA69, C-terminal domain

  11. XM_063286743.1 → XP_063142813.1  islet cell autoantigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A739, A6IDX7
    Related
    ENSRNOP00000086969.1, ENSRNOT00000100899.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63054.2 GenPept UniProtKB/Swiss-Prot:Q63054

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