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IFT88 intraflagellar transport 88 [ Homo sapiens (human) ]

Gene ID: 8100, updated on 27-Nov-2024

Summary

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Official Symbol
IFT88provided by HGNC
Official Full Name
intraflagellar transport 88provided by HGNC
Primary source
HGNC:HGNC:20606
See related
Ensembl:ENSG00000032742 MIM:600595; AllianceGenome:HGNC:20606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAF19; TG737; TTC10; hTg737; D13S1056E
Summary
This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 23.5), thyroid (RPKM 6.6) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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See IFT88 in Genome Data Viewer
Location:
13q12.11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20567157..20691444)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19760320..19884580)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21141296..21265583)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene crystallin lambda 1 Neighboring gene microRNA 4499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21067481-21067980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21076097-21077093 Neighboring gene Sharpr-MPRA regulatory region 6807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7425 Neighboring gene Sharpr-MPRA regulatory region 3329 Neighboring gene uncharacterized LOC105370103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5154 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:21141501-21141689 Neighboring gene solute carrier family 35 member E1 pseudogene 1 Neighboring gene RNA, U2 small nuclear 7, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene interleukin 17D Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. Schrick JJ, et al. Hum Mol Genet, 1995 Apr. PMID 7633404
  2. Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis. Song Z, et al. Mol Biol Rep, 2010 Dec. PMID 20300861
  3. The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. Robert A, et al. J Cell Sci, 2007 Feb 15. PMID 17264151
  4. Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells. You N, et al. J Exp Clin Cancer Res, 2012 Sep 13. PMID 22974282, Free PMC Article
  5. MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737. Zhao G, et al. World J Gastroenterol, 2016 Jun 21. PMID 27340352, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor.
    Title: Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor.
  2. Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma.
    Title: Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma.
  3. IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
    Title: IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles.
  4. The Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
    Title: Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis.
  5. Significant association was found between IFT88 rs9509311 and rs2497490 and Nonsyndromic cleft lip with or without cleft palate (NSCLP) in non-Hispanic white families (p = .004 and .005), while nominal associations were found for rs7998361 and rs9509307 (p < .05). Pairwise association analyses also showed nominal associations between NSCLP in both NHW and Hispanic data sets (p < .05).
    Title: Association of IFT88 gene variants with nonsyndromic cleft lip with or without cleft palate.
  6. TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening
    Title: Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
  7. These observations suggest that the rare and unique combination of IFT88 alleles observed in this study provide insight into the physiological role of IFT88 in humans and the likely mechanism underlying retinal pathology in the pedigree with inherited retinal degeneration
    Title: IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis.
  8. IFT88/primary cilia play a role in metabolic reprogramming in thyroid cancer cells.
    Title: Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
  9. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured chondrocytes.
    Title: Basic fibroblast growth factor increases IFT88 expression in chondrocytes.
  10. Data suggest that the function of the fusion transcript crystallin, lambda 1 protein - intraflagellar transport 88 (CRYL1-IFT88) is closed to CRYL1 because it contained most of domain of CRYL1.
    Title: Transcriptome profiling identifies a recurrent CRYL1-IFT88 chimeric transcript in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
EBI GWAS Catalog
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in inner ear receptor cell stereocilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to silicon dioxide IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary tip TAS
Traceable Author Statement
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of intraciliary transport particle B IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in manchette ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm head-tail coupling apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 88 homolog
Names
TPR repeat protein 10
intraflagellar transport 88 homolog
polaris homolog
probe hTg737 (polycystic kidney disease, autosomal recessive)
recessive polycystic kidney disease protein Tg737 homolog
testicular tissue protein Li 93
tetratricopeptide repeat domain 10
tetratricopeptide repeat protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318491.2 → NP_001305420.1  intraflagellar transport protein 88 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple alternate exons in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300769, AL161772, BC030776, BG182322
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (6) summary
    sd00006
    Location:465 → 493
    TPR; TPR repeat [structural motif]
    cd15832
    Location:210 → 241
    SNAP; TPR repeat [structural motif]
    pfam00515
    Location:500 → 524
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:464 → 528
    TPR_11; TPR repeat
    pfam13424
    Location:216 → 285
    TPR_12; Tetratricopeptide repeat
    cl24038
    Location:210 → 311
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  2. NM_001318493.2 → NP_001305422.1  intraflagellar transport protein 88 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional segment in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AK126668, AK308281, AL161772, BC059357, BG182322
    Consensus CDS
    CCDS31944.1
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:493 → 521
    TPR; TPR repeat [structural motif]
    cl26002
    Location:222 → 730
    TPR_11; TPR repeat

  3. NM_001353565.2 → NP_001340494.1  intraflagellar transport protein 88 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AL161772, AL590096
    Consensus CDS
    CCDS31944.1
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:493 → 521
    TPR; TPR repeat [structural motif]
    cl26002
    Location:222 → 730
    TPR_11; TPR repeat

  4. NM_001353566.2 → NP_001340495.1  intraflagellar transport protein 88 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 4, 6, and 8, encodes isoform 1.
    Source sequence(s)
    AL161772, AL590096
    Consensus CDS
    CCDS31944.1
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:493 → 521
    TPR; TPR repeat [structural motif]
    cl26002
    Location:222 → 730
    TPR_11; TPR repeat

  5. NM_001353567.2 → NP_001340496.1  intraflagellar transport protein 88 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 4, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AL161772, AL590096
    Consensus CDS
    CCDS31944.1
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:493 → 521
    TPR; TPR repeat [structural motif]
    cl26002
    Location:222 → 730
    TPR_11; TPR repeat

  6. NM_001353568.2 → NP_001340497.1  intraflagellar transport protein 88 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AL161772, AL590096
    Consensus CDS
    CCDS31945.1
    UniProtKB/Swiss-Prot
    A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
    UniProtKB/TrEMBL
    A0A140VJL7, B3KX42
    Conserved Domains (2) summary
    TIGR02917
    Location:213 → 721
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:484 → 512
    TPR; TPR repeat [structural motif]

  7. NM_001353569.2 → NP_001340498.1  intraflagellar transport protein 88 homolog isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    COG0457
    Location:235 → 509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:459 → 487
    TPR; TPR repeat [structural motif]
    cl26002
    Location:397 → 666
    TPR_11; TPR repeat

  8. NM_001353570.2 → NP_001340499.1  intraflagellar transport protein 88 homolog isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    COG0457
    Location:235 → 509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:459 → 487
    TPR; TPR repeat [structural motif]
    cl26002
    Location:397 → 666
    TPR_11; TPR repeat

  9. NM_001353571.2 → NP_001340500.1  intraflagellar transport protein 88 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    smart00028
    Location:238 → 265
    TPR; Tetratricopeptide repeats
    sd00006
    Location:450 → 478
    TPR; TPR repeat [structural motif]
    cl26002
    Location:388 → 657
    TPR_11; TPR repeat

  10. NM_001353572.2 → NP_001340501.1  intraflagellar transport protein 88 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:484 → 512
    TPR; TPR repeat [structural motif]
    cl26002
    Location:213 → 721
    TPR_11; TPR repeat

  11. NM_001353573.2 → NP_001340502.1  intraflagellar transport protein 88 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:436 → 464
    TPR; TPR repeat [structural motif]
    cl26002
    Location:184 → 664
    TPR_11; TPR repeat

  12. NM_001353574.2 → NP_001340503.1  intraflagellar transport protein 88 homolog isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    smart00028
    Location:219 → 246
    TPR; Tetratricopeptide repeats
    sd00006
    Location:431 → 459
    TPR; TPR repeat [structural motif]
    cl26002
    Location:369 → 638
    TPR_11; TPR repeat

  13. NM_001353575.2 → NP_001340504.1  intraflagellar transport protein 88 homolog isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (2) summary
    sd00006
    Location:465 → 493
    TPR; TPR repeat [structural motif]
    cl26002
    Location:194 → 674
    TPR_11; TPR repeat

  14. NM_001353576.2 → NP_001340505.1  intraflagellar transport protein 88 homolog isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variantm18, encodes isoform 11.
    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    COG0457
    Location:235 → 509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:459 → 487
    TPR; TPR repeat [structural motif]
    cl26002
    Location:397 → 666
    TPR_11; TPR repeat

  15. NM_001353577.2 → NP_001340506.1  intraflagellar transport protein 88 homolog isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 17, encodes isoform 11.
    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    COG0457
    Location:235 → 509
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:459 → 487
    TPR; TPR repeat [structural motif]
    cl26002
    Location:397 → 666
    TPR_11; TPR repeat

  16. NM_001353578.2 → NP_001340507.1  intraflagellar transport protein 88 homolog isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    smart00028
    Location:238 → 265
    TPR; Tetratricopeptide repeats
    sd00006
    Location:450 → 478
    TPR; TPR repeat [structural motif]
    cl26002
    Location:388 → 657
    TPR_11; TPR repeat

  17. NM_001353579.2 → NP_001340508.1  intraflagellar transport protein 88 homolog isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096
    Conserved Domains (2) summary
    sd00006
    Location:273 → 301
    TPR; TPR repeat [structural motif]
    cl26002
    Location:2 → 510
    TPR_11; TPR repeat

  18. NM_006531.5 → NP_006522.2  intraflagellar transport protein 88 homolog isoform 2

    See identical proteins and their annotated locations for NP_006522.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate exons in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 9 both encode the same isoform (2).
    Source sequence(s)
    AK126668, AK308281, AK310223, AL161772, BC059357, BG182322
    Consensus CDS
    CCDS31945.1
    UniProtKB/Swiss-Prot
    A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
    UniProtKB/TrEMBL
    A0A140VJL7, B3KX42
    Related
    ENSP00000261632.5, ENST00000351808.10
    Conserved Domains (2) summary
    TIGR02917
    Location:213 → 721
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:484 → 512
    TPR; TPR repeat [structural motif]

  19. NM_175605.5 → NP_783195.2  intraflagellar transport protein 88 homolog isoform 1

    See identical proteins and their annotated locations for NP_783195.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 6, 7, and 8 all encode the same isoform (1).
    Source sequence(s)
    AK126668, AL161772, BC030776, BG182322
    Consensus CDS
    CCDS31944.1
    UniProtKB/TrEMBL
    B3KX42
    Related
    ENSP00000323580.6, ENST00000319980.10
    Conserved Domains (2) summary
    sd00006
    Location:493 → 521
    TPR; TPR repeat [structural motif]
    cl26002
    Location:222 → 730
    TPR_11; TPR repeat

RNA

  1. NR_134653.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs at both the 5' and 3' ends, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126668, AK310223, AL161772, BC059357, BG182322

  2. NR_148462.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096

  3. NR_148463.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096

  4. NR_148464.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096

  5. NR_148465.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161772, AL590096

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    20567157..20691444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430655.1 → XP_047286611.1  intraflagellar transport protein 88 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
    UniProtKB/TrEMBL
    A0A140VJL7

  2. XM_017020757.2 → XP_016876246.1  intraflagellar transport protein 88 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
    UniProtKB/TrEMBL
    A0A140VJL7, B3KX42
    Conserved Domains (2) summary
    TIGR02917
    Location:213 → 721
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:484 → 512
    TPR; TPR repeat [structural motif]

  3. XM_017020763.2 → XP_016876252.1  intraflagellar transport protein 88 homolog isoform X8

    UniProtKB/TrEMBL
    B3KX42

  4. XM_017020762.2 → XP_016876251.1  intraflagellar transport protein 88 homolog isoform X6

    UniProtKB/TrEMBL
    B3KX42

  5. XM_024449413.2 → XP_024305181.1  intraflagellar transport protein 88 homolog isoform X12

    UniProtKB/TrEMBL
    B3KX42
    Conserved Domains (3) summary
    smart00028
    Location:228 → 255
    TPR; Tetratricopeptide repeats
    sd00006
    Location:440 → 468
    TPR; TPR repeat [structural motif]
    cl26002
    Location:378 → 647
    TPR_11; TPR repeat

  6. XM_047430660.1 → XP_047286616.1  intraflagellar transport protein 88 homolog isoform X4

  7. XM_047430670.1 → XP_047286626.1  intraflagellar transport protein 88 homolog isoform X14

  8. XM_047430656.1 → XP_047286612.1  intraflagellar transport protein 88 homolog isoform X2

  9. XM_047430661.1 → XP_047286617.1  intraflagellar transport protein 88 homolog isoform X5

  10. XM_047430671.1 → XP_047286627.1  intraflagellar transport protein 88 homolog isoform X14

  11. XM_047430667.1 → XP_047286623.1  intraflagellar transport protein 88 homolog isoform X11

  12. XM_047430662.1 → XP_047286618.1  intraflagellar transport protein 88 homolog isoform X6

  13. XM_047430659.1 → XP_047286615.1  intraflagellar transport protein 88 homolog isoform X4

  14. XM_047430657.1 → XP_047286613.1  intraflagellar transport protein 88 homolog isoform X2

  15. XM_047430668.1 → XP_047286624.1  intraflagellar transport protein 88 homolog isoform X12

  16. XM_006719870.4 → XP_006719933.1  intraflagellar transport protein 88 homolog isoform X1

    See identical proteins and their annotated locations for XP_006719933.1

    UniProtKB/Swiss-Prot
    A2A491, B4DUS2, Q13099, Q5SZJ6, Q8N719
    UniProtKB/TrEMBL
    A0A140VJL7, B3KX42
    Conserved Domains (2) summary
    TIGR02917
    Location:213 → 721
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:484 → 512
    TPR; TPR repeat [structural motif]

  17. XM_047430666.1 → XP_047286622.1  intraflagellar transport protein 88 homolog isoform X10

  18. XM_047430665.1 → XP_047286621.1  intraflagellar transport protein 88 homolog isoform X9

  19. XM_047430658.1 → XP_047286614.1  intraflagellar transport protein 88 homolog isoform X3

  20. XM_047430663.1 → XP_047286619.1  intraflagellar transport protein 88 homolog isoform X7

  21. XM_047430674.1 → XP_047286630.1  intraflagellar transport protein 88 homolog isoform X17

  22. XM_047430673.1 → XP_047286629.1  intraflagellar transport protein 88 homolog isoform X16

  23. XM_047430672.1 → XP_047286628.1  intraflagellar transport protein 88 homolog isoform X15

  24. XM_047430675.1 → XP_047286631.1  intraflagellar transport protein 88 homolog isoform X18

  25. XM_047430669.1 → XP_047286625.1  intraflagellar transport protein 88 homolog isoform X13

  26. XM_047430664.1 → XP_047286620.1  intraflagellar transport protein 88 homolog isoform X8

  27. XM_047430676.1 → XP_047286632.1  intraflagellar transport protein 88 homolog isoform X19

  28. XM_017020775.2 → XP_016876264.1  intraflagellar transport protein 88 homolog isoform X20

  29. XM_017020776.2 → XP_016876265.1  intraflagellar transport protein 88 homolog isoform X23

  30. XM_047430679.1 → XP_047286635.1  intraflagellar transport protein 88 homolog isoform X25

  31. XM_047430678.1 → XP_047286634.1  intraflagellar transport protein 88 homolog isoform X24

  32. XM_024449415.2 → XP_024305183.1  intraflagellar transport protein 88 homolog isoform X21

    Conserved Domains (2) summary
    COG0457
    Location:199 → 352
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:247 → 270
    TPR; TPR repeat [structural motif]

  33. XM_047430677.1 → XP_047286633.1  intraflagellar transport protein 88 homolog isoform X22

RNA

  1. XR_007063700.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    19760320..19884580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375008.1 → XP_054230983.1  intraflagellar transport protein 88 homolog isoform X1

  2. XM_054375009.1 → XP_054230984.1  intraflagellar transport protein 88 homolog isoform X1

  3. XM_054375020.1 → XP_054230995.1  intraflagellar transport protein 88 homolog isoform X8

  4. XM_054375016.1 → XP_054230991.1  intraflagellar transport protein 88 homolog isoform X6

  5. XM_054375024.1 → XP_054230999.1  intraflagellar transport protein 88 homolog isoform X12

  6. XM_054375014.1 → XP_054230989.1  intraflagellar transport protein 88 homolog isoform X4

  7. XM_054375027.1 → XP_054231002.1  intraflagellar transport protein 88 homolog isoform X14

  8. XM_054375010.1 → XP_054230985.1  intraflagellar transport protein 88 homolog isoform X2

  9. XM_054375015.1 → XP_054230990.1  intraflagellar transport protein 88 homolog isoform X5

  10. XM_054375028.1 → XP_054231003.1  intraflagellar transport protein 88 homolog isoform X14

  11. XM_054375023.1 → XP_054230998.1  intraflagellar transport protein 88 homolog isoform X11

  12. XM_054375017.1 → XP_054230992.1  intraflagellar transport protein 88 homolog isoform X6

  13. XM_054375013.1 → XP_054230988.1  intraflagellar transport protein 88 homolog isoform X4

  14. XM_054375011.1 → XP_054230986.1  intraflagellar transport protein 88 homolog isoform X2

  15. XM_054375025.1 → XP_054231000.1  intraflagellar transport protein 88 homolog isoform X12

  16. XM_054375007.1 → XP_054230982.1  intraflagellar transport protein 88 homolog isoform X1

  17. XM_054375022.1 → XP_054230997.1  intraflagellar transport protein 88 homolog isoform X10

  18. XM_054375021.1 → XP_054230996.1  intraflagellar transport protein 88 homolog isoform X9

  19. XM_054375012.1 → XP_054230987.1  intraflagellar transport protein 88 homolog isoform X3

  20. XM_054375018.1 → XP_054230993.1  intraflagellar transport protein 88 homolog isoform X7

  21. XM_054375031.1 → XP_054231006.1  intraflagellar transport protein 88 homolog isoform X17

  22. XM_054375030.1 → XP_054231005.1  intraflagellar transport protein 88 homolog isoform X16

  23. XM_054375029.1 → XP_054231004.1  intraflagellar transport protein 88 homolog isoform X15

  24. XM_054375032.1 → XP_054231007.1  intraflagellar transport protein 88 homolog isoform X18

  25. XM_054375026.1 → XP_054231001.1  intraflagellar transport protein 88 homolog isoform X13

  26. XM_054375019.1 → XP_054230994.1  intraflagellar transport protein 88 homolog isoform X8

  27. XM_054375033.1 → XP_054231008.1  intraflagellar transport protein 88 homolog isoform X19

  28. XM_054375035.1 → XP_054231010.1  intraflagellar transport protein 88 homolog isoform X26

  29. XM_054375034.1 → XP_054231009.1  intraflagellar transport protein 88 homolog isoform X20

  30. XM_054375038.1 → XP_054231013.1  intraflagellar transport protein 88 homolog isoform X23

  31. XM_054375040.1 → XP_054231015.1  intraflagellar transport protein 88 homolog isoform X25

  32. XM_054375039.1 → XP_054231014.1  intraflagellar transport protein 88 homolog isoform X24

  33. XM_054375037.1 → XP_054231012.1  intraflagellar transport protein 88 homolog isoform X22

  34. XM_054375036.1 → XP_054231011.1  intraflagellar transport protein 88 homolog isoform X21

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13099.3 GenPept UniProtKB/Swiss-Prot:Q13099

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