papss2b 3'-phosphoadenosine 5'-phosphosulfate synthase 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: papss2bprovided by ZNC
Official Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010323-5
See related: Ensembl:ENSDARG00000056600 AllianceGenome:ZFIN:ZDB-GENE-010323-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Papss1; papss2; sb:cb868; zgc:55851; zgc:85655; id:ibd2761; wu:fb12e05
Summary: Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Is expressed in several structures, including digestive system; mesoderm; pectoral fin; pectoral fin bud; and sensory system. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (17458949..17479078, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (17337075..17357204, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fe02a02.y1 (e-PCR)
- UniSTS:195927

fb12e05.x1 (e-PCR)
- UniSTS:202871

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylylsulfate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylylsulfate kinase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfate adenylyltransferase (ATP) activity	IEA Inferred from Electronic Annotation more info
enables sulfate adenylyltransferase (ATP) activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate assimilation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sulfate assimilation	IEA Inferred from Electronic Annotation more info
involved_in sulfate assimilation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b

Names: 3'-phosphoadenosine 5'-phosphosulfate synthase 2

NP_997727.1

EC 2.7.7.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212562.1 → NP_997727.1 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b

See identical proteins and their annotated locations for NP_997727.1

Status: PROVISIONAL

Source sequence(s)

BC047190

UniProtKB/TrEMBL

Q6NV20, Q802U9

Related

ENSDARP00000073570.4, ENSDART00000079115.5

Conserved Domains (3) summary

cd00517
Location:243 → 606

ATPS; ATP-sulfurylase

cd02027
Location:43 → 193

APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

TIGR00339
Location:234 → 605

sopT; ATP sulphurylase