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cd4-1 CD4-1 molecule [ Danio rerio (zebrafish) ]

Gene ID: 799982, updated on 12-Jan-2025

Summary

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Official Symbol
cd4-1provided by ZNC
Official Full Name
CD4-1 moleculeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-280
See related
Ensembl:ENSDARG00000070668 AllianceGenome:ZFIN:ZDB-GENE-100922-280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cd4; CD4-3; cd4-4; CD4L-1
Summary
Located in cell surface. Is expressed in blood; digestive system; gill; immune system; and muscle. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cd4-1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (11911903..11946191, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12021001..12055289, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) receptor 3, tandem duplicate 3 Neighboring gene chemokine (C-X-C motif) receptor 3, tandem duplicate 1 Neighboring gene CD4-2 molecule, tandem duplicate 1 Neighboring gene CD4-2 molecule, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cross-reactivity of monoclonal antibodies against CD4-1 and CD8α of ginbuna crucian carp with lymphocytes of zebrafish and other cyprinid species. Miyazawa R, et al. Dev Comp Immunol, 2018 Mar. PMID 27965016
  2. Probiotic expressing heterologous phytase improves the immune system and attenuates inflammatory response in zebrafish fed with a diet rich in soybean meal. Santos KO, et al. Fish Shellfish Immunol, 2019 Oct. PMID 31412282
  3. CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia. Cardoso BA, et al. Haematologica, 2024 Jun 1. PMID 38058200, Free PMC Article
  4. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Sun Z, et al. Fish Shellfish Immunol, 2015 Oct. PMID 26256425
  5. Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia. Oliveira ML, et al. Leukemia, 2022 Jun. PMID 35581375, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD4-1 molecule
Names
CD4 molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135096.1 → NP_001128568.1  CD4-1 molecule precursor

    See identical proteins and their annotated locations for NP_001128568.1

    Status: PROVISIONAL

    Source sequence(s)
    EF601917
    UniProtKB/TrEMBL
    B5KH12
    Related
    ENSDARP00000149025.1, ENSDART00000183229.1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    11911903..11946191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173496.5 → XP_005173553.1  CD4-1 molecule isoform X1

    See identical proteins and their annotated locations for XP_005173553.1

    UniProtKB/TrEMBL
    A0A8M2BKU2, F1QZB1, F1QZB2, U6C9E1
    Related
    ENSDARP00000121210.1, ENSDART00000133787.3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394955.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    244786..258576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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