apln apelin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aplnprovided by ZNC
Official Full Name: apelinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070521-8
See related: Ensembl:ENSDARG00000053279 AllianceGenome:ZFIN:ZDB-GENE-070521-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables apelin receptor binding activity. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within several processes, including cell migration involved in mesendoderm migration; circulatory system development; and mesodermal cell migration. Predicted to be located in extracellular region. Is expressed in several structures, including axial chorda mesoderm; axis; cardiovascular system; digestive system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human APLN (apelin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (33722950..33757715)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (33382636..33417401)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR25 is activated by Apelin protein.
Title: The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates.
Apelin signaling regulates lymphatic development by promoting serine-threonine kinase Akt/protein kinase B activity in a VEGF-C/VEGF receptor 3-independent manner during zebrafish embryogenesis.
Title: Essential role of Apelin signaling during lymphatic development in zebrafish.
Apelin knockdown inhibits both hypoxia-induced endothelial cell proliferation in vitro and hypoxia-induced vessel regeneration in the caudal fin regeneration of zebrafish.
Title: Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables apelin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables apelin receptor binding	IEA Inferred from Electronic Annotation more info
enables apelin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables apelin receptor binding	TAS Traceable Author Statement more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration involved in gastrulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration involved in mesendoderm migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect determination of liver left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drinking behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apelin

Names: APJ endogenous ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.