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ZMYM1 zinc finger MYM-type containing 1 [ Homo sapiens (human) ]

Gene ID: 79830, updated on 27-Nov-2024

Summary

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Official Symbol
ZMYM1provided by HGNC
Official Full Name
zinc finger MYM-type containing 1provided by HGNC
Primary source
HGNC:HGNC:26253
See related
Ensembl:ENSG00000197056 AllianceGenome:HGNC:26253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM
Summary
Predicted to enable protein dimerization activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 3.0), ovary (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ZMYM1 in Genome Data Viewer
Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (35059786..35118818)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (34922450..34978527)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35525387..35581460)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903990 Neighboring gene ribosomal protein L12 pseudogene 45 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35544893-35545411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:35555322-35555822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 722 Neighboring gene EF-hand calcium binding domain 14 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35594172-35594351 Neighboring gene uncharacterized LOC105378644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article
  2. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, et al. Mol Cell, 2018 Dec 6. PMID 30415952
  3. Identification and functional characterization of transcriptional activators in human cells. Alerasool N, et al. Mol Cell, 2022 Feb 3. PMID 35016035
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. So J, et al. Sci Signal, 2015 Apr 7. PMID 25852190
  5. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23151, FLJ43753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger MYM-type protein 1
Names
zinc finger, MYM domain containing 1
zinc finger, MYM-type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289088.2 → NP_001276017.1  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AK026804, AK125741, BC037313, BX537537
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    D3DPR7, Q5SVZ6, Q7Z3Q4
    UniProtKB/TrEMBL
    B4DSJ9
    Related
    ENSP00000482579.1, ENST00000611874.4
    Conserved Domains (5) summary
    smart00597
    Location:452 → 531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135 → 175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:1029 → 1118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83 → 121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496 → 728
    DUF4371; Domain of unknown function (DUF4371)

  2. NM_001289089.2 → NP_001276018.1  zinc finger MYM-type protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AL607089
    UniProtKB/TrEMBL
    B4DSJ9
    Conserved Domains (4) summary
    smart00597
    Location:433 → 512
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:1010 → 1099
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:130 → 171
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:477 → 709
    DUF4371; Domain of unknown function (DUF4371)

  3. NM_001289090.2 → NP_001276019.1  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AL607089
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    D3DPR7, Q5SVZ6, Q7Z3Q4
    UniProtKB/TrEMBL
    B4DSJ9
    Related
    ENSP00000362427.1, ENST00000373330.1
    Conserved Domains (5) summary
    smart00597
    Location:452 → 531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135 → 175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:1029 → 1118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83 → 121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496 → 728
    DUF4371; Domain of unknown function (DUF4371)

  4. NM_001289091.2 → NP_001276020.1  zinc finger MYM-type protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AL607089
    UniProtKB/TrEMBL
    B4DSJ9, Q9H5R2
    Conserved Domains (3) summary
    smart00597
    Location:92 → 171
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:700 → 758
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:133 → 367
    DUF4371; Domain of unknown function (DUF4371)

  5. NM_001319955.2 → NP_001306884.1  zinc finger MYM-type protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL607089
    UniProtKB/TrEMBL
    B4DSJ9
    Related
    ENST00000373329.5
    Conserved Domains (5) summary
    smart00597
    Location:377 → 456
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:60 → 100
    TRASH; metallochaperone-like domain
    pfam05699
    Location:954 → 1043
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:8 → 46
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:421 → 653
    DUF4371; Domain of unknown function (DUF4371)

  6. NM_024772.5 → NP_079048.3  zinc finger MYM-type protein 1 isoform a

    See identical proteins and their annotated locations for NP_079048.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform a).
    Source sequence(s)
    AL607089
    Consensus CDS
    CCDS41302.1
    UniProtKB/Swiss-Prot
    D3DPR7, Q5SVZ6, Q7Z3Q4
    UniProtKB/TrEMBL
    B4DSJ9
    Related
    ENSP00000352920.4, ENST00000359858.9
    Conserved Domains (5) summary
    smart00597
    Location:452 → 531
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:135 → 175
    TRASH; metallochaperone-like domain
    pfam05699
    Location:1029 → 1118
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:83 → 121
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:496 → 728
    DUF4371; Domain of unknown function (DUF4371)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    35059786..35118818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430815.1 → XP_047286771.1  zinc finger MYM-type protein 1 isoform X9

  2. XM_047430816.1 → XP_047286772.1  zinc finger MYM-type protein 1 isoform X7

  3. XM_047430818.1 → XP_047286774.1  zinc finger MYM-type protein 1 isoform X8

  4. XM_047430777.1 → XP_047286733.1  zinc finger MYM-type protein 1 isoform X2

  5. XM_047430783.1 → XP_047286739.1  zinc finger MYM-type protein 1 isoform X3

  6. XM_047430786.1 → XP_047286742.1  zinc finger MYM-type protein 1 isoform X1

  7. XM_011542166.4 → XP_011540468.3  zinc finger MYM-type protein 1 isoform X7

    Related
    ENSP00000394233.1, ENST00000417119.5

  8. XM_047430814.1 → XP_047286770.1  zinc finger MYM-type protein 1 isoform X8

  9. XM_011542163.4 → XP_011540465.3  zinc finger MYM-type protein 1 isoform X1

  10. XM_017002358.2 → XP_016857847.1  zinc finger MYM-type protein 1 isoform X4

    UniProtKB/TrEMBL
    B4DSJ9
    Conserved Domains (5) summary
    smart00597
    Location:377 → 456
    ZnF_TTF; zinc finger in transposases and transcription factors
    smart00746
    Location:60 → 100
    TRASH; metallochaperone-like domain
    pfam05699
    Location:954 → 1043
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam06467
    Location:8 → 46
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam14291
    Location:421 → 653
    DUF4371; Domain of unknown function (DUF4371)

  11. XM_024449827.2 → XP_024305595.1  zinc finger MYM-type protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DSJ9
    Conserved Domains (3) summary
    smart00597
    Location:261 → 340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838 → 927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302 → 536
    DUF4371; Domain of unknown function (DUF4371)

  12. XM_047430803.1 → XP_047286759.1  zinc finger MYM-type protein 1 isoform X5

  13. XM_024449824.2 → XP_024305592.1  zinc finger MYM-type protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DSJ9
    Conserved Domains (3) summary
    smart00597
    Location:261 → 340
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:838 → 927
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:302 → 536
    DUF4371; Domain of unknown function (DUF4371)

  14. XM_024449833.2 → XP_024305601.1  zinc finger MYM-type protein 1 isoform X6

    Conserved Domains (3) summary
    smart00597
    Location:92 → 171
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:700 → 758
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
    pfam14291
    Location:133 → 367
    DUF4371; Domain of unknown function (DUF4371)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    34922450..34978527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338785.1 → XP_054194760.1  zinc finger MYM-type protein 1 isoform X2

  2. XM_054338795.1 → XP_054194770.1  zinc finger MYM-type protein 1 isoform X9

  3. XM_054338786.1 → XP_054194761.1  zinc finger MYM-type protein 1 isoform X3

  4. XM_054338783.1 → XP_054194758.1  zinc finger MYM-type protein 1 isoform X10

  5. XM_054338793.1 → XP_054194768.1  zinc finger MYM-type protein 1 isoform X12

  6. XM_054338784.1 → XP_054194759.1  zinc finger MYM-type protein 1 isoform X11

  7. XM_054338794.1 → XP_054194769.1  zinc finger MYM-type protein 1 isoform X13

  8. XM_054338796.1 → XP_054194771.1  zinc finger MYM-type protein 1 isoform X7

  9. XM_054338787.1 → XP_054194762.1  zinc finger MYM-type protein 1 isoform X1

  10. XM_054338797.1 → XP_054194772.1  zinc finger MYM-type protein 1 isoform X8

  11. XM_054338788.1 → XP_054194763.1  zinc finger MYM-type protein 1 isoform X4

  12. XM_054338789.1 → XP_054194764.1  zinc finger MYM-type protein 1 isoform X5

  13. XM_054338790.1 → XP_054194765.1  zinc finger MYM-type protein 1 isoform X5

  14. XM_054338791.1 → XP_054194766.1  zinc finger MYM-type protein 1 isoform X5

  15. XM_054338792.1 → XP_054194767.1  zinc finger MYM-type protein 1 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SVZ6.1 GenPept UniProtKB/Swiss-Prot:Q5SVZ6

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