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ARHGAP28 Rho GTPase activating protein 28 [ Homo sapiens (human) ]

Gene ID: 79822, updated on 27-Nov-2024

Summary

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Official Symbol
ARHGAP28provided by HGNC
Official Full Name
Rho GTPase activating protein 28provided by HGNC
Primary source
HGNC:HGNC:25509
See related
Ensembl:ENSG00000088756 MIM:610592; AllianceGenome:HGNC:25509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of stress fiber assembly; regulation of actin filament polymerization; and regulation of small GTPase mediated signal transduction. Located in cell junction and nucleoplasm. Implicated in allergic disease. Biomarker of meningioma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 21.0), placenta (RPKM 7.7) and 10 other tissues See more
Orthologs
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Genomic context

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See ARHGAP28 in Genome Data Viewer
Location:
18p11.31
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (6729716..6915716)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (6890201..7076260)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (6729715..6915715)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1387 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6557353-6558046 Neighboring gene uncharacterized LOC105371972 Neighboring gene uncharacterized LOC107985176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:6570281-6571070 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:6571071-6571861 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:6575977-6576203 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:6605546-6606358 Neighboring gene RNA, 7SL, cytoplasmic 282, pseudogene Neighboring gene ARHGAP28 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6729485-6730448 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740450-6740950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:6740951-6741451 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6751961-6752536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:6752537-6753112 Neighboring gene NANOG hESC enhancer GRCh37_chr18:6782830-6783412 Neighboring gene long intergenic non-protein coding RNA 668 Neighboring gene RNA, U6 small nuclear 916, pseudogene Neighboring gene SCML2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of substance dependence phenotypes in the COGA sample. Wetherill L, et al. Addict Biol, 2015 May. PMID 24832863, Free PMC Article
  2. Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. Yeung CY, et al. PLoS One, 2014. PMID 25211221, Free PMC Article
  3. DNA sequence and analysis of human chromosome 18. Nusbaum C, et al. Nature, 2005 Sep 22. PMID 16177791
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10312, FLJ27160, DKFZp686A2038

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 28
Names
rho-type GTPase-activating protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010000.3 → NP_001010000.1  rho GTPase-activating protein 28 isoform a

    See identical proteins and their annotated locations for NP_001010000.1

    Status: VALIDATED

    Source sequence(s)
    AI435330, AK302026, AP005210, BX648684
    Consensus CDS
    CCDS32785.1
    UniProtKB/TrEMBL
    E9PMX7
    Related
    ENSP00000392660.2, ENST00000419673.6
    Conserved Domains (1) summary
    cd04391
    Location:218 → 429
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  2. NM_001366230.1 → NP_001353159.1  rho GTPase-activating protein 28 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP005205, AP005210
    Consensus CDS
    CCDS92429.1
    UniProtKB/Swiss-Prot
    A8MQB7, A8MU88, Q6P160, Q8N4T3, Q9NW53, Q9P2N2
    Related
    ENSP00000372964.4, ENST00000383472.9
    Conserved Domains (1) summary
    cd04391
    Location:377 → 588
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  3. NM_001366231.1 → NP_001353160.1  rho GTPase-activating protein 28 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP005205, AP005210
    Conserved Domains (1) summary
    cd04391
    Location:377 → 588
    RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  4. NM_001410873.1 → NP_001397802.1  rho GTPase-activating protein 28 isoform e

    Status: VALIDATED

    Source sequence(s)
    AP005205, AP005210
    Consensus CDS
    CCDS92430.1
    Related
    ENSP00000262227.3, ENST00000262227.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    6729716..6915716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258146.3 → XP_005258203.1  rho GTPase-activating protein 28 isoform X1

    Conserved Domains (1) summary
    cd04391
    Location:395 → 580
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  2. XM_047437794.1 → XP_047293750.1  rho GTPase-activating protein 28 isoform X2

  3. XM_047437799.1 → XP_047293755.1  rho GTPase-activating protein 28 isoform X3

  4. XM_047437796.1 → XP_047293752.1  rho GTPase-activating protein 28 isoform X4

  5. XM_047437795.1 → XP_047293751.1  rho GTPase-activating protein 28 isoform X3

  6. XM_047437797.1 → XP_047293753.1  rho GTPase-activating protein 28 isoform X3

  7. XM_047437798.1 → XP_047293754.1  rho GTPase-activating protein 28 isoform X3

  8. XM_047437800.1 → XP_047293756.1  rho GTPase-activating protein 28 isoform X3

  9. XM_047437801.1 → XP_047293757.1  rho GTPase-activating protein 28 isoform X3

  10. XM_047437803.1 → XP_047293759.1  rho GTPase-activating protein 28 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    6890201..7076260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319100.1 → XP_054175075.1  rho GTPase-activating protein 28 isoform X1

  2. XM_054319101.1 → XP_054175076.1  rho GTPase-activating protein 28 isoform X2

  3. XM_054319106.1 → XP_054175081.1  rho GTPase-activating protein 28 isoform X3

  4. XM_054319103.1 → XP_054175078.1  rho GTPase-activating protein 28 isoform X4

  5. XM_054319102.1 → XP_054175077.1  rho GTPase-activating protein 28 isoform X3

  6. XM_054319104.1 → XP_054175079.1  rho GTPase-activating protein 28 isoform X3

  7. XM_054319105.1 → XP_054175080.1  rho GTPase-activating protein 28 isoform X3

  8. XM_054319107.1 → XP_054175082.1  rho GTPase-activating protein 28 isoform X3

  9. XM_054319108.1 → XP_054175083.1  rho GTPase-activating protein 28 isoform X3

  10. XM_054319109.1 → XP_054175084.1  rho GTPase-activating protein 28 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030672.2: Suppressed sequence

    Description
    NM_030672.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2N2.3 GenPept UniProtKB/Swiss-Prot:Q9P2N2

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