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ZNF668 zinc finger protein 668 [ Homo sapiens (human) ]

Gene ID: 79759, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF668provided by HGNC
Official Full Name
zinc finger protein 668provided by HGNC
Primary source
HGNC:HGNC:25821
See related
Ensembl:ENSG00000167394 MIM:617103; AllianceGenome:HGNC:25821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDGEF
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in DNA repair. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 2.2), bone marrow (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF668 in Genome Data Viewer
Location:
16p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31060847..31074240, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31448267..31461668, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31072168..31085561, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31001361-31002004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31002005-31002648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7407 Neighboring gene syntaxin 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31011808-31012308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31012309-31012809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31021995-31022496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31044203-31044714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31045227-31045737 Neighboring gene syntaxin 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31074971-31075598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31075599-31076226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31084437-31085237 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31085443-31085976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31085977-31086509 Neighboring gene zinc finger protein 646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31099941-31100441 Neighboring gene serine protease 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31104343-31105051 Neighboring gene vitamin K epoxide reductase complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF668 deficiency causes a recognizable disorder of DNA damage repair. Alsaif HS, et al. Hum Genet, 2021 Sep. PMID 34313816
  2. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Hu R, et al. Cell Cycle, 2013 Jul 1. PMID 23777805, Free PMC Article
  3. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Hu R, et al. Cancer Res, 2011 Oct 15. PMID 21852383, Free PMC Article
  4. The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. Cámara-Quílez M, et al. Cancers (Basel), 2020 Aug 27. PMID 32867128, Free PMC Article
  5. Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening. Falconieri A, et al. Cancers (Basel), 2022 Feb 17. PMID 35205757, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF668 deficiency causes a recognizable disorder of DNA damage repair.
    Title: ZNF668 deficiency causes a recognizable disorder of DNA damage repair.
  2. ZNF668 is a key molecule that links chromatin relaxation with DNA damage response in DNA repair control.
    Title: Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage.
  3. ZNF668 was identified as a novel breast tumor suppressor protein that regeulates the stability p53 tumor suppression proteins.
    Title: ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies
MedGen: C5774288 OMIM: 620194 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13479, FLJ14492

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 668

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172668.2 → NP_001166139.1  zinc finger protein 668 isoform a

    See identical proteins and their annotated locations for NP_001166139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AB209710, AC135050, AK027398, AK289899, DC412389
    Consensus CDS
    CCDS10701.1
    UniProtKB/Swiss-Prot
    C9JHH8, F5H7E7, Q59EV1, Q8N669, Q96K58, Q9H8L4
    UniProtKB/TrEMBL
    A8K1I4
    Related
    ENSP00000440149.1, ENST00000538906.5
    Conserved Domains (3) summary
    COG5048
    Location:80 → 414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:86 → 106
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001172669.2 → NP_001166140.1  zinc finger protein 668 isoform b

    See identical proteins and their annotated locations for NP_001166140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate 5' coding exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB209710, AK023541, DA450347
    Consensus CDS
    CCDS54003.1
    UniProtKB/TrEMBL
    A8K1I4
    Related
    ENSP00000442573.3, ENST00000539836.3
    Conserved Domains (4) summary
    COG5048
    Location:103 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249 → 269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:109 → 129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233 → 258
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001172670.2 → NP_001166141.1  zinc finger protein 668 isoform a

    See identical proteins and their annotated locations for NP_001166141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AB209710, AK023541, AK308239
    Consensus CDS
    CCDS10701.1
    UniProtKB/Swiss-Prot
    C9JHH8, F5H7E7, Q59EV1, Q8N669, Q96K58, Q9H8L4
    UniProtKB/TrEMBL
    A8K1I4
    Related
    ENSP00000441349.1, ENST00000535577.5
    Conserved Domains (3) summary
    COG5048
    Location:80 → 414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:86 → 106
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_024706.5 → NP_078982.3  zinc finger protein 668 isoform a

    See identical proteins and their annotated locations for NP_078982.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AB209710, AC135050, AK023541, BC021997
    Consensus CDS
    CCDS10701.1
    UniProtKB/Swiss-Prot
    C9JHH8, F5H7E7, Q59EV1, Q8N669, Q96K58, Q9H8L4
    UniProtKB/TrEMBL
    A8K1I4
    Related
    ENSP00000300849.4, ENST00000300849.5
    Conserved Domains (3) summary
    COG5048
    Location:80 → 414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:86 → 106
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31060847..31074240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31448267..31461668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96K58.4 GenPept UniProtKB/Swiss-Prot:Q96K58

Gene LinkOut

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