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card9 caspase recruitment domain family, member 9 [ Danio rerio (zebrafish) ]

Gene ID: 796425, updated on 4-Jan-2025

Summary

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Official Symbol
card9provided by ZNC
Official Full Name
caspase recruitment domain family, member 9provided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-94
See related
Ensembl:ENSDARG00000067672 AllianceGenome:ZFIN:ZDB-GENE-060531-94
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-1o2.6
Summary
Predicted to act upstream of or within regulation of apoptotic process. Is expressed in brain; gill; liver; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See card9 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (51156808..51167466, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50510215..50520621, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:194398 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene coiled-coil domain containing 180 Neighboring gene small nuclear RNA activating complex, polypeptide 4 Neighboring gene endosome associated trafficking regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. Brewer WJ, et al. Cell Rep, 2022 Dec 13. PMID 36516756, Free PMC Article
  2. NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Mai Y, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Feb. PMID 33161151
  3. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Chang MX, et al. Dev Comp Immunol, 2010 Jan. PMID 19699229
  4. Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Zhao S, et al. Nat Commun, 2018 Jul 6. PMID 29980668, Free PMC Article
  5. Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Hu P, et al. Sci Rep, 2016 Jun 30. PMID 27356472, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
caspase recruitment domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110285.2 → NP_001103755.1  caspase recruitment domain-containing protein 9

    Status: VALIDATED

    Source sequence(s)
    CU856180
    UniProtKB/TrEMBL
    A0A8M1NGG8, A0A8M3AZX7, A2CE85
    Related
    ENSDARP00000088242.5, ENSDART00000097471.5
    Conserved Domains (1) summary
    cl14633
    Location:16 → 101
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    51156808..51167466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301789.4 → XP_009300064.1  caspase recruitment domain-containing protein 9 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AZX7, A0A8M3B2T4
    Conserved Domains (1) summary
    cd08809
    Location:16 → 101
    CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

  2. XM_009301788.4 → XP_009300063.1  caspase recruitment domain-containing protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASS5, A0A8M3AZX7
    Conserved Domains (2) summary
    cd08809
    Location:37 → 122
    CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins
    cl23765
    Location:242 → 359
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. XM_009301786.4 → XP_009300061.1  caspase recruitment domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASN6, A0A8M3AZX7
    Conserved Domains (2) summary
    cd08809
    Location:37 → 122
    CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins
    cl23765
    Location:242 → 359
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. XM_009301787.4 → XP_009300062.1  caspase recruitment domain-containing protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AZX7, A0A8M3B9W3
    Conserved Domains (1) summary
    cd08809
    Location:37 → 122
    CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

  5. XM_005165527.5 → XP_005165584.1  caspase recruitment domain-containing protein 9 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BD15, A0A8M3AZX7
    Conserved Domains (1) summary
    cd08809
    Location:37 → 122
    CARD_CARD9; Caspase activation and recruitment domain of CARD9-like proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    287721..296938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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