dnajc6 DnaJ (Hsp40) homolog, subfamily C, member 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnajc6provided by ZNC
Official Full Name: DnaJ (Hsp40) homolog, subfamily C, member 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-080104-2
See related: Ensembl:ENSDARG00000079891 AllianceGenome:ZFIN:ZDB-GENE-080104-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable clathrin binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle uncoating. Located in cytosol and perinuclear region of cytoplasm. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (31279562..31348830, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (31292648..31362045, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative tyrosine-protein phosphatase auxilin; auxilin

Names: Aux

XP_009300747.1

EC 3.1.3.48

XP_021327454.1

EC 3.1.3.48

XP_021327455.1

EC 3.1.3.48

XP_021327456.1

EC 3.1.3.48

XP_021327457.1

EC 3.1.3.48

XP_021329773.1

EC 3.1.3.48

XP_021329774.1

EC 3.1.3.48

XP_021329776.1

EC 3.1.3.48

XP_021329777.1

EC 3.1.3.48

XP_021332834.1

EC 3.1.3.48

XP_021332835.1

EC 3.1.3.48

XP_021332836.1

EC 3.1.3.48

XP_021332837.1

EC 3.1.3.48

XP_068078097.1

EC 3.1.3.48

XP_068078098.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

31279562..31348830 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068221997.1 → XP_068078098.1 auxilin isoform X7

UniProtKB/TrEMBL

A0A8M9Q0M0

Related

ENSDARP00000129415.1, ENSDART00000153734.2
XM_068221996.1 → XP_068078097.1 auxilin isoform X4

UniProtKB/TrEMBL

A0A8M9Q0M0
XM_021477160.2 → XP_021332835.1 auxilin isoform X2

UniProtKB/TrEMBL

A0A8M9Q0M0, A0A8M9QG43

Conserved Domains (3) summary

cd06257
Location:922 → 963

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:280 → 415

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:533 → 837

Atrophin-1; Atrophin-1 family
XM_009302472.4 → XP_009300747.1 auxilin isoform X3

UniProtKB/TrEMBL

A0A8M3B0J3, A0A8M9Q0M0

Related

ENSDARP00000154903.1, ENSDART00000193927.1

Conserved Domains (2) summary

cd06257
Location:918 → 959

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:285 → 420

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_021477162.2 → XP_021332837.1 auxilin isoform X6

UniProtKB/TrEMBL

A0A8M9PMW6, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:896 → 937

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:285 → 420

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:539 → 810

Atrophin-1; Atrophin-1 family
XM_021477161.2 → XP_021332836.1 auxilin isoform X5

UniProtKB/TrEMBL

A0A8M9Q0M0, A0A8M9QB30

Conserved Domains (3) summary

cd06257
Location:902 → 943

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:285 → 420

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:538 → 817

Atrophin-1; Atrophin-1 family
XM_021477159.2 → XP_021332834.1 auxilin isoform X1

UniProtKB/TrEMBL

A0A8M9Q0M0, A0A8M9Q6X2

Conserved Domains (3) summary

cd06257
Location:927 → 968

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:285 → 420

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:538 → 842

Atrophin-1; Atrophin-1 family

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394650.1 Reference GRCz11 ALT_DRER_TU_1

Range

463700..494005 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021471782.2 → XP_021327457.1 auxilin isoform X11

UniProtKB/TrEMBL

A0A8M9P987, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:690 → 731

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:333 → 604

Atrophin-1; Atrophin-1 family
XM_021471781.2 → XP_021327456.1 auxilin isoform X10

UniProtKB/TrEMBL

A0A8M9PYN9, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:696 → 737

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:332 → 611

Atrophin-1; Atrophin-1 family
XM_021471779.2 → XP_021327454.1 auxilin isoform X8

UniProtKB/TrEMBL

A0A8M9PRF3, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:721 → 762

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:332 → 636

Atrophin-1; Atrophin-1 family
XM_021471780.2 → XP_021327455.1 auxilin isoform X9

UniProtKB/TrEMBL

A0A8M9Q0M0, A0A8M9Q219

Conserved Domains (3) summary

cd06257
Location:712 → 753

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:323 → 627

Atrophin-1; Atrophin-1 family

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395257.1 Reference GRCz11 ALT_DRER_TU_2

Range

163224..190864 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474102.2 → XP_021329777.1 auxilin isoform X15

UniProtKB/TrEMBL

A0A8M9PF24, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:690 → 731

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:333 → 609

Atrophin-1; Atrophin-1 family
XM_021474101.2 → XP_021329776.1 auxilin isoform X14

UniProtKB/TrEMBL

A0A8M9Q0M0, A0A8M9Q4I9

Conserved Domains (3) summary

cd06257
Location:696 → 737

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:339 → 611

Atrophin-1; Atrophin-1 family
XM_021474098.2 → XP_021329773.1 auxilin isoform X12

UniProtKB/TrEMBL

A0A8M9PRW9, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:721 → 762

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:339 → 636

Atrophin-1; Atrophin-1 family
XM_021474099.2 → XP_021329774.1 auxilin isoform X13

UniProtKB/TrEMBL

A0A8M9PY08, A0A8M9Q0M0

Conserved Domains (3) summary

cd06257
Location:712 → 753

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

pfam10409
Location:79 → 214

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:330 → 627

Atrophin-1; Atrophin-1 family