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toporsb topoisomerase I binding, arginine/serine-rich b [ Danio rerio (zebrafish) ]

Gene ID: 796087, updated on 4-Jan-2025

Summary

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Official Symbol
toporsbprovided by ZNC
Official Full Name
topoisomerase I binding, arginine/serine-rich bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110728-3
See related
Ensembl:ENSDARG00000105028 AllianceGenome:ZFIN:ZDB-GENE-110728-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
topors; wu:fi75f04
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein monoubiquitination and protein polyubiquitination. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See toporsb in Genome Data Viewer
Location:
chromosome: Un
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003336480.1 (21112..34380)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336480.1 (21093..34382)

NW_003336480.1Genomic Context describing neighboring genes Neighboring gene atrial natriuretic peptide receptor 1 Neighboring gene uncharacterized LOC100333722 Neighboring gene RNA sensor RIG-I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration. Powell C, et al. J Biol Chem, 2014 Oct 17. PMID 25190811, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Topors

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003336480.1 Reference GRCz11 Primary Assembly

    Range
    21112..34380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003201632.6 → XP_003201680.1  E3 ubiquitin-protein ligase Topors

    UniProtKB/TrEMBL
    A0A0R4ICA2, A0A8M1RPD6
    Related
    ENSDARP00000130234.1, ENSDART00000161495.2
    Conserved Domains (1) summary
    cd00162
    Location:32 → 75
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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