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Chrna1 cholinergic receptor nicotinic alpha 1 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 79557, updated on 27-Nov-2024

Summary

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Official Symbol
Chrna1provided by RGD
Official Full Name
cholinergic receptor nicotinic alpha 1 subunitprovided by RGD
Primary source
RGD:69277
See related
EnsemblRapid:ENSRNOG00000018286 AllianceGenome:RGD:69277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Orthologous to human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 33.4), Heart (RPKM 3.8) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Chrna1 in Genome Data Viewer
Location:
3q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78862286..78877353, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58454763..58469832, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60445657..60460724, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ring-box 1, pseudogene 2 Neighboring gene uncharacterized LOC108350398 Neighboring gene uncharacterized LOC134486115 Neighboring gene serpin family B member 8 like 1 Neighboring gene chimerin 1 Neighboring gene uncharacterized LOC134486114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of ongoing experimental myasthenia by oral treatment with an acetylcholine receptor recombinant fragment. Im SH, et al. J Clin Invest, 1999 Dec. PMID 10606626, Free PMC Article
  2. Quinidine sulfate therapy for the slow-channel congenital myasthenic syndrome. Harper CM, et al. Ann Neurol, 1998 Apr. PMID 9546329
  3. Allele-specific silencing of a pathogenic mutant acetylcholine receptor subunit by RNA interference. Abdelgany A, et al. Hum Mol Genet, 2003 Oct 15. PMID 12928480
  4. Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. Milone M, et al. J Neurosci, 1997 Aug 1. PMID 9221765, Free PMC Article
  5. Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle. Witzemann V, et al. Eur J Biochem, 1990 Dec 12. PMID 1702709

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to acetylcholine binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of acetylcholine-gated channel complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetylcholine receptor subunit alpha
Names
cholinergic receptor nicotinic alpha polypeptide 1
cholinergic receptor, nicotinic, alpha 1 (muscle)
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024485.2 → NP_077811.1  acetylcholine receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_077811.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P25108
    UniProtKB/TrEMBL
    A6HMA0, A6HMA1
    Related
    ENSRNOP00000024706.3, ENSRNOT00000024706.6
    Conserved Domains (3) summary
    TIGR00860
    Location:21 → 447
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 231
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:238 → 446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    78862286..78877353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25108.1 GenPept UniProtKB/Swiss-Prot:P25108

Gene LinkOut

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