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c4b complement C4B (Chido/Rodgers blood group) [ Danio rerio (zebrafish) ]

Gene ID: 794635, updated on 4-Jan-2025

Summary

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Official Symbol
c4bprovided by ZNC
Official Full Name
complement C4B (Chido/Rodgers blood group)provided by ZNC
Primary source
ZFIN:ZDB-GENE-100805-2
See related
Ensembl:ENSDARG00000038424 AllianceGenome:ZFIN:ZDB-GENE-100805-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c4-2; c4bl; si:dkey-8k3.2
Summary
Predicted to enable endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See c4b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (16665203..16701780, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (16757225..16793965, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 21, subfamily A, polypeptide 2 Neighboring gene tenascin XBa Neighboring gene urotensin-2 receptor 3 Neighboring gene potassium inwardly rectifying channel subfamily J member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fish complement C4 gene evolution and gene/protein regulatory network analyses and simulated stereo conformation of C4-MASP-2 protein complex. Li L, et al. Fish Shellfish Immunol, 2020 Dec. PMID 32980531
  2. Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Wang D, et al. Neurotoxicol Teratol, 2020 May-Jun. PMID 32240749
  3. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Chernyavskaya Y, et al. Development, 2017 Aug 15. PMID 28698226, Free PMC Article
  4. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article
  5. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C4-B
Names
complement 4B (Chido blood group)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365137.1 → NP_001352066.1  complement C4-B

    Status: VALIDATED

    Source sequence(s)
    FP929006
    UniProtKB/TrEMBL
    A0A8M1Q1D0
    Related
    ENSDARP00000115743.1, ENSDART00000143550.3
    Conserved Domains (7) summary
    cd00017
    Location:667 → 735
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:982 → 1299
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    cd03584
    Location:1563 → 1715
    NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
    pfam00207
    Location:772 → 854
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:130 → 224
    A2M_N; MG2 domain
    pfam07677
    Location:1456 → 1545
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:452 → 593
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    16665203..16701780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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