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WDR25 WD repeat domain 25 [ Homo sapiens (human) ]

Gene ID: 79446, updated on 27-Nov-2024

Summary

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Official Symbol
WDR25provided by HGNC
Official Full Name
WD repeat domain 25provided by HGNC
Primary source
HGNC:HGNC:21064
See related
Ensembl:ENSG00000176473 MIM:618059; AllianceGenome:HGNC:21064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf67
Summary
This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

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See WDR25 in Genome Data Viewer
Location:
14q32.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (100376485..100530303)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (94609583..94764104)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100842822..100996640)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9038 Neighboring gene solute carrier family 25 member 47 Neighboring gene tryptophanyl-tRNA synthetase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100837597-100838513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6091 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100848141-100849101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100849328-100849837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100860083-100860587 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:100863901-100865100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100870227-100870728 Neighboring gene uncharacterized LOC105370664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876203-100876704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876705-100877204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100885967-100886468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100886469-100886968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100893614-100894278 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:100904917-100906116 Neighboring gene Sharpr-MPRA regulatory region 12420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100913795-100914295 Neighboring gene uncharacterized LOC124903383 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100932314-100933219 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100966138-100966638 Neighboring gene RN7SK pseudogene 92 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100989077-100989737 Neighboring gene uncharacterized LOC124903382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9041 Neighboring gene uncharacterized LOC124903384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101021873-101022628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101022629-101023385 Neighboring gene brain enriched guanylate kinase associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. Jin F, et al. Biochem Genet, 2004 Dec. PMID 15587985
  2. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Jung JG, et al. PLoS Genet, 2014 Oct. PMID 25356737, Free PMC Article
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
  4. The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation. Nelson CB, et al. Nat Commun, 2024 Feb 15. PMID 38360978, Free PMC Article
  5. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4645

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
WD repeat-containing protein 25
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053195.1 RefSeqGene

    Range
    5076..158894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161476.3 → NP_001154948.1  WD repeat-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_001154948.1

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552
    Consensus CDS
    CCDS32157.1
    UniProtKB/Swiss-Prot
    A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
    UniProtKB/TrEMBL
    A0A384NPW5
    Related
    ENSP00000385540.3, ENST00000402312.8
    Conserved Domains (2) summary
    sd00039
    Location:251 → 290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:239 → 543
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001350947.2 → NP_001337876.1  WD repeat-containing protein 25 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552
    Consensus CDS
    CCDS32157.1
    UniProtKB/Swiss-Prot
    A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
    UniProtKB/TrEMBL
    A0A384NPW5
    Conserved Domains (2) summary
    sd00039
    Location:251 → 290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:239 → 543
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001350948.2 → NP_001337877.1  WD repeat-containing protein 25 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552
    Consensus CDS
    CCDS32157.1
    UniProtKB/Swiss-Prot
    A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
    UniProtKB/TrEMBL
    A0A384NPW5
    Related
    ENSP00000450661.1, ENST00000554998.5
    Conserved Domains (2) summary
    sd00039
    Location:251 → 290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:239 → 543
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001350949.2 → NP_001337878.1  WD repeat-containing protein 25 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552
    Conserved Domains (2) summary
    sd00039
    Location:46 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:15 → 293
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_001387351.1 → NP_001374280.1  WD repeat-containing protein 25 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552
    Related
    ENSP00000441903.2, ENST00000542471.2
    Conserved Domains (2) summary
    sd00039
    Location:46 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:15 → 293
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_024515.6 → NP_078791.3  WD repeat-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_078791.3

    Status: REVIEWED

    Source sequence(s)
    AL135838, AL845552, AY295082, BG705426, HY044677
    Consensus CDS
    CCDS32157.1
    UniProtKB/Swiss-Prot
    A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
    UniProtKB/TrEMBL
    A0A384NPW5
    Related
    ENSP00000334148.6, ENST00000335290.10
    Conserved Domains (2) summary
    sd00039
    Location:251 → 290
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:239 → 543
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    100376485..100530303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431772.1 → XP_047287728.1  WD repeat-containing protein 25 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    94609583..94764104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001350950.1: Suppressed sequence

    Description
    NM_001350950.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64LD2.3 GenPept UniProtKB/Swiss-Prot:Q64LD2

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