gdnfa glial cell derived neurotrophic factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gdnfaprovided by ZNC
Official Full Name: glial cell derived neurotrophic factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010226-1
See related: Ensembl:ENSDARG00000039959 AllianceGenome:ZFIN:ZDB-GENE-010226-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gdnf
Summary: Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (1396925..1413737)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (1384179..1400991)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A two-site flexible clamp mechanism for RET-GDNF-GFRalpha1 assembly reveals both conformational adaptation and strict geometric spacing.
Title: A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.
gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish.
Title: gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish.
results contradict previous studies suggesting that mammalian GFRalpha1 and GDNF cannot bind and activate non-mammalian RET and vice versa
Title: Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro.
the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain
Title: [Expression of gdnf and nos in adult zebrafish brain during the regeneration after spinal cord injury].
GDNF family ligands including tyrosine kinase receptor RET are investigated within the adult zebrafish brain.
Title: GDNF family ligand RET receptor in the brain of adult zebrafish.
GDNF is a major determinant of directed neuritic growth , and GDNF acts by promoting local neurite outgrowth.
Title: Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish.
These results demonstrated the expression of the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of GDNF in Purkinje cells.
Title: Glial cell line-derived neurotrophic factor in Purkinje cells of adult zebrafish: an autocrine mode of action?
These results showed that the expression of GDNF is not probably restricted during development but it might be involved in the physiology of adult zebrafish retina.
Title: Glial cell line-derived neurotrophic factor expression in the retina of adult zebrafish (Danio rerio).
The expression of glial cell line-derived neurotrophic factor (GDNF) was not restricted to developmental periods but it seems that this factor might be involved in adult zebrafish brain physiology, as observed in mammals.
Title: Glial cell line-derived neurotrophic factor expression in the brain of adult zebrafish (Danio rerio).

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General gene information

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Markers

fb09c06.x1 (e-PCR)
- UniSTS:189980

fk30g07.y1 (e-PCR)
- UniSTS:200785

fc02h08.x1 (e-PCR)
- UniSTS:192089

fj04f02.x1 (e-PCR)
- UniSTS:198364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MAP kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glial cell-derived neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within diencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info
involved_in enteric nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in peristalsis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in postganglionic parasympathetic fiber development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of dopamine uptake involved in synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of morphogenesis of a branching structure	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glial cell line-derived neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131732.2 → NP_571807.2 glial cell line-derived neurotrophic factor precursor

Status: VALIDATED

Source sequence(s)

CU914630, CU928210, EH115133

UniProtKB/Swiss-Prot

Q98TU0

UniProtKB/TrEMBL

A0A8N7UZM6, A7E220

Related

ENSDARP00000124666.1, ENSDART00000150096.2

Conserved Domains (1) summary

pfam00019
Location:140 → 234

TGF_beta; Transforming growth factor beta like domain