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mocs1 molybdenum cofactor synthesis 1 [ Danio rerio (zebrafish) ]

Gene ID: 793471, updated on 9-Dec-2024

Summary

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Official Symbol
mocs1provided by ZNC
Official Full Name
molybdenum cofactor synthesis 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-130215-1
See related
Ensembl:ENSDARG00000078479 AllianceGenome:ZFIN:ZDB-GENE-130215-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mocs1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (41337246..41369313)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (41348372..41380931)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene FOS like 2, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC137488132 Neighboring gene uncharacterized LOC108179794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP 3',8'-cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
molybdenum cofactor biosynthesis protein 1
Names
molybdenum cofactor synthesis step-1
NP_001099130.2
XP_009291513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105660.2 → NP_001099130.2  molybdenum cofactor biosynthesis protein 1

    Status: VALIDATED

    Source sequence(s)
    CABZ01038567, CR381689
    UniProtKB/TrEMBL
    A0A8M1NEB2, F1R905
    Related
    ENSDARP00000099913.2, ENSDART00000111238.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    41337246..41369313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293238.4 → XP_009291513.1  molybdenum cofactor biosynthesis protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJ79
    Conserved Domains (4) summary
    cd01335
    Location:91 → 288
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PRK09364
    Location:578 → 733
    moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
    TIGR02666
    Location:78 → 401
    moaA; molybdenum cofactor biosynthesis protein A, bacterial
    pfam06463
    Location:258 → 384
    Mob_synth_C; Molybdenum Cofactor Synthesis C
Nucleotide Protein Strain
Heading Accession and Version

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