Frk fyn-related Src family tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frkprovided by RGD
Official Full Name: fyn-related Src family tyrosine kinaseprovided by RGD
Primary source: RGD:621423
See related: EnsemblRapid:ENSRNOG00000000543 AllianceGenome:RGD:621423
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein tyrosine kinase activity. Involved in cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 70.3), Liver (RPKM 62.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (39820441..39926065)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (38265416..38371038)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (41266408..41383731)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fyn kinase is associated with sodium channels in brain neurons and can modulate Na(v)1.2 channels by tyrosine phosphorylation after activation of TrkB/p75 neurotrophin receptor signaling by brain-derived neurotrophic factor (BDNF).
Title: Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase.
The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131763 (e-PCR)
- UniSTS:215046

RH132991 (e-PCR)
- UniSTS:216274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase FRK

Names: GASK; GTK; fyn-related kinase; gastrointestinal-associated kinase; gastrointestinal-associated tyrosine kinase; src related tyrosine kinase

NP_077344.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024368.2 → NP_077344.1 tyrosine-protein kinase FRK

See identical proteins and their annotated locations for NP_077344.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q62662

UniProtKB/TrEMBL

A0A8L2PZJ9, A6KID2

Related

ENSRNOP00000000653.7, ENSRNOT00000000653.8

Conserved Domains (4) summary

cd10369
Location:113 → 208

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:48 → 105

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:226 → 495

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

pfam07714
Location:235 → 488

Pkinase_Tyr; Protein tyrosine kinase