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lrrc15 leucine rich repeat containing 15 [ Danio rerio (zebrafish) ]

Gene ID: 791200, updated on 9-Dec-2024

Summary

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Official Symbol
lrrc15provided by ZNC
Official Full Name
leucine rich repeat containing 15provided by ZNC
Primary source
ZFIN:ZDB-GENE-031113-8
See related
Ensembl:ENSDARG00000070792 AllianceGenome:ZFIN:ZDB-GENE-031113-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb894; zgc:158286
Summary
Predicted to enable Roundabout binding activity and heparin binding activity. Predicted to be involved in axon guidance and negative chemotaxis. Predicted to be located in membrane. Is expressed in cardiovascular system; hematopoietic system; ventral mesoderm; and yolk syncytial layer. Orthologous to human LRRC15 (leucine rich repeat containing 15). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See lrrc15 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (36459977..36463700)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (36482083..36485806)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:dkey-117a16.1 Neighboring gene Rh family, C glycoprotein, like 1 Neighboring gene uncharacterized LOC137495989 Neighboring gene uncharacterized LOC137490239 Neighboring gene hairy-related 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dual role of Jam3b in early hematopoietic and vascular development. Kobayashi I, et al. Development, 2020 Jan 8. PMID 31852685
  2. Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. Kuretani A, et al. BMC Ecol Evol, 2021 Jul 29. PMID 34325655, Free PMC Article
  3. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
  4. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080682.1 → NP_001074151.1  leucine-rich repeat-containing protein 15 precursor

    See identical proteins and their annotated locations for NP_001074151.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129189
    UniProtKB/TrEMBL
    A1L1S0
    Related
    ENSDARP00000095023.3, ENSDART00000104248.4
    Conserved Domains (6) summary
    smart00013
    Location:21 → 48
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:163 → 253
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:171 → 194
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:241 → 280
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:170 → 229
    LRR_8; Leucine rich repeat
    cl15307
    Location:418 → 467
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    36459977..36463700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394657.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    105231..108953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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