pde8a phosphodiesterase 8A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pde8aprovided by ZNC
Official Full Name: phosphodiesterase 8Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-622
See related: Ensembl:ENSDARG00000087941 AllianceGenome:ZFIN:ZDB-GENE-070112-622
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158458
Summary: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling; cellular response to epidermal growth factor stimulus; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16378..33817, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16378..33817, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fi26d03.y1 (e-PCR)
- UniSTS:197126

G45473 (e-PCR)
- UniSTS:106275

z1795 (e-PCR), detects polymorphism
- UniSTS:205153

G45056 (e-PCR)
- UniSTS:105858

z53416 (e-PCR), detects polymorphism
- UniSTS:238490

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to epidermal growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

NP_001074096.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080627.1 → NP_001074096.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Status: PROVISIONAL

Source sequence(s)

BC129238

UniProtKB/TrEMBL

A1L1W3

Related

ENSDARP00000107237.3, ENSDART00000129125.3

Conserved Domains (5) summary

COG0745
Location:67 → 158

OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]

cd00130
Location:215 → 311

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd00156
Location:68 → 155

REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

pfam00233
Location:541 → 792

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam13426
Location:211 → 307

PAS_9; PAS domain