Bcam basal cell adhesion molecule (Lutheran blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcamprovided by RGD
Official Full Name: basal cell adhesion molecule (Lutheran blood group)provided by RGD
Primary source: RGD:68378
See related: EnsemblRapid:ENSRNOG00000029399 AllianceGenome:RGD:68378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lu
Summary: Predicted to enable laminin binding activity and laminin receptor activity. Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human BCAM (basal cell adhesion molecule (Lutheran blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1098.4), Heart (RPKM 641.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88542971..88557358, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79415016..79429403, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80674463..80689122, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
Title: BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling.
Data indicate that the 14-3-3beta-FBI1/Akirin2 complex bound to the basal cell adhesion molecule (BCAM) promoter and repressed transcription.
Title: The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables laminin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables laminin receptor activity	IEA Inferred from Electronic Annotation more info
enables laminin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: basal cell adhesion molecule

Names: B-CAM cell surface glycoprotein; Lutheran blood group (Auberger b antigen included); lutheran antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031752.2 → NP_113940.1 basal cell adhesion molecule precursor

See identical proteins and their annotated locations for NP_113940.1

Status: PROVISIONAL

Source sequence(s)

BC072479

UniProtKB/Swiss-Prot

Q9ESS6

UniProtKB/TrEMBL

A0A8I6A1Q0

Related

ENSRNOP00000047809.4, ENSRNOT00000045574.6

Conserved Domains (4) summary

smart00408
Location:376 → 424

IGc2; Immunoglobulin C-2 Type

smart00410
Location:32 → 137

IG_like; Immunoglobulin like

pfam08205
Location:145 → 242

C2-set_2; CD80-like C2-set immunoglobulin domain

cl11960
Location:448 → 522

Ig; Immunoglobulin domain