Spink8 serine peptidase inhibitor, Kazal type 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spink8provided by MGI
Official Full Name: serine peptidase inhibitor, Kazal type 8provided by MGI
Primary source: MGI:MGI:1925959
See related: Ensembl:ENSMUSG00000050074 AllianceGenome:MGI:1925959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C630041L24Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system; and liver. Orthologous to human SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 783.7) See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.77 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (109641271..109655696)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (109812203..109826628)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

General gene information

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Markers

Spink8 (e-PCR), detects polymorphism
- UniSTS:526095

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183136.2 → NP_898959.2 serine protease inhibitor Kazal-type 8 precursor

See identical proteins and their annotated locations for NP_898959.2

Status: VALIDATED

Source sequence(s)

AW455991, BC048588, CN843460

Consensus CDS

CCDS40777.1

UniProtKB/Swiss-Prot

Q09TK9

UniProtKB/TrEMBL

Q8C1F8

Related

ENSMUSP00000142586.2, ENSMUST00000198988.5

Conserved Domains (1) summary

cl00097
Location:49 → 96

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

109641271..109655696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512398.5 → XP_006512461.1 serine protease inhibitor Kazal-type 8 isoform X1

See identical proteins and their annotated locations for XP_006512461.1

UniProtKB/Swiss-Prot

Q09TK9

UniProtKB/TrEMBL

Q8C1F8

Conserved Domains (1) summary

cl00097
Location:49 → 96

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...