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Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Mus musculus (house mouse) ]

Gene ID: 78618, updated on 27-Nov-2024

Summary

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Official Symbol
Acap2provided by MGI
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by MGI
Primary source
MGI:MGI:1925868
See related
Ensembl:ENSMUSG00000049076 AllianceGenome:MGI:1925868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNT-B2; Centb2; mKIAA0041; 4832442G16; 9530039J15Rik
Summary
Enables phosphatidylinositol-3,5-bisphosphate binding activity and small GTPase binding activity. Predicted to be involved in cellular response to nerve growth factor stimulus and endocytic recycling. Predicted to act upstream of or within actin filament-based process. Predicted to be located in ruffle. Predicted to be active in endosome membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 7.0), frontal lobe adult (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Acap2 in Genome Data Viewer
Location:
16 B2; 16 21.34 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30911230..31020105, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31092412..31201285, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene xyloside xylosyltransferase 1 Neighboring gene predicted gene, 41440 Neighboring gene STARR-positive B cell enhancer ABC_E7437 Neighboring gene STARR-positive B cell enhancer ABC_E11610 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:31081520-31081703 Neighboring gene predicted gene, 46554 Neighboring gene zinc finger protein 161 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40608 Neighboring gene STARR-positive B cell enhancer ABC_E4163 Neighboring gene STARR-positive B cell enhancer ABC_E7438 Neighboring gene predicted gene, 52237 Neighboring gene STARR-seq mESC enhancer starr_40609 Neighboring gene predicted gene, 41442 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis. Egami Y, et al. J Cell Sci, 2011 Nov 1. PMID 22045739
  2. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
  3. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2013 Jun 1. PMID 23572513
  4. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
  5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.
    Title: Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Names
centaurin, beta 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030138.2 → NP_084414.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_084414.1

    Status: VALIDATED

    Source sequence(s)
    AC090430, AK129041, BB465902, BY014253
    Consensus CDS
    CCDS49823.1
    UniProtKB/Swiss-Prot
    Q3UHL4, Q6ZQK5, Q811F3, Q9CTS8
    Related
    ENSMUSP00000154983.2, ENSMUST00000230614.2
    Conserved Domains (7) summary
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    smart00105
    Location:402 → 518
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:602 → 718
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 361
    PH; PH domain
    pfam12796
    Location:602 → 696
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:630 → 663
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30911230..31020105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522747.5 → XP_006522810.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A338P6P6
    Related
    ENSMUSP00000156077.2, ENSMUST00000229010.3
    Conserved Domains (7) summary
    PTZ00322
    Location:669 → 753
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:387 → 624
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:269 → 365
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:665 → 698
    ANK; ANK repeat [structural motif]
    cd08851
    Location:399 → 513
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:637 → 688
    Ank_4; Ankyrin repeats (many copies)

  2. XM_006522746.5 → XP_006522809.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

    Conserved Domains (7) summary
    PTZ00322
    Location:673 → 757
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:391 → 628
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:273 → 369
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:669 → 702
    ANK; ANK repeat [structural motif]
    cd08851
    Location:403 → 517
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:641 → 692
    Ank_4; Ankyrin repeats (many copies)

  3. XM_006522743.5 → XP_006522806.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

    Conserved Domains (7) summary
    PTZ00322
    Location:680 → 764
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:398 → 635
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:273 → 376
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:676 → 709
    ANK; ANK repeat [structural motif]
    cd08851
    Location:410 → 524
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:648 → 699
    Ank_4; Ankyrin repeats (many copies)

  4. XM_006522749.5 → XP_006522812.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006522812.1

    UniProtKB/TrEMBL
    D4AFX6
    Related
    ENSMUSP00000154852.2, ENSMUST00000231125.2
    Conserved Domains (6) summary
    PTZ00322
    Location:641 → 725
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:637 → 670
    ANK; ANK repeat [structural motif]
    cd08851
    Location:406 → 520
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:609 → 660
    Ank_4; Ankyrin repeats (many copies)

  5. XM_006522744.5 → XP_006522807.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

    Conserved Domains (7) summary
    PTZ00322
    Location:676 → 760
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    COG5347
    Location:394 → 631
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:269 → 372
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:672 → 705
    ANK; ANK repeat [structural motif]
    cd08851
    Location:406 → 520
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:644 → 695
    Ank_4; Ankyrin repeats (many copies)

  6. XM_006522748.5 → XP_006522811.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X5

    Conserved Domains (6) summary
    PTZ00322
    Location:645 → 729
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:273 → 376
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:641 → 674
    ANK; ANK repeat [structural motif]
    cd08851
    Location:410 → 524
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:613 → 664
    Ank_4; Ankyrin repeats (many copies)

  7. XM_017317162.2 → XP_017172651.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7

    Conserved Domains (6) summary
    PTZ00322
    Location:638 → 722
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd07638
    Location:18 → 217
    BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
    cd13250
    Location:273 → 369
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:634 → 667
    ANK; ANK repeat [structural motif]
    cd08851
    Location:403 → 517
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:606 → 657
    Ank_4; Ankyrin repeats (many copies)

  8. XM_017317163.3 → XP_017172652.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    Conserved Domains (7) summary
    PTZ00322
    Location:489 → 573
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5347
    Location:207 → 444
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:82 → 185
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:485 → 518
    ANK; ANK repeat [structural motif]
    cd08851
    Location:219 → 333
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:457 → 508
    Ank_4; Ankyrin repeats (many copies)
    cl12013
    Location:1 → 47
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_036160182.1 → XP_036016075.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X8

    Conserved Domains (7) summary
    PTZ00322
    Location:489 → 573
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5347
    Location:207 → 444
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    cd13250
    Location:82 → 185
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:485 → 518
    ANK; ANK repeat [structural motif]
    cd08851
    Location:219 → 333
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:457 → 508
    Ank_4; Ankyrin repeats (many copies)
    cl12013
    Location:1 → 47
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_017317164.3 → XP_017172653.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X9

    Conserved Domains (6) summary
    PTZ00322
    Location:443 → 527
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd13250
    Location:78 → 174
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:439 → 472
    ANK; ANK repeat [structural motif]
    cd08851
    Location:208 → 322
    ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)
    pfam13637
    Location:411 → 462
    Ank_4; Ankyrin repeats (many copies)
    cl12013
    Location:1 → 47
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_384614.5 RNA Sequence

  2. XR_384613.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQK5.2 GenPept UniProtKB/Swiss-Prot:Q6ZQK5

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