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Tmsb15a thymosin beta 15a [ Mus musculus (house mouse) ]

Gene ID: 78478, updated on 27-Nov-2024

Summary

Official Symbol
Tmsb15aprovided by MGI
Official Full Name
thymosin beta 15aprovided by MGI
Primary source
MGI:MGI:1925728
See related
Ensembl:ENSMUSG00000060726 AllianceGenome:MGI:1925728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tb15a; Tmsl8; Tmsbl1; 1700129I15Rik
Summary
Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to be active in cytoplasm. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human TMSB15A (thymosin beta 15A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 4.8) See more
Orthologs
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Genomic context

See Tmsb15a in Genome Data Viewer
Location:
X F1; X 57.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134619416..134626010, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135718667..135725261, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene PRAME like, X-linked 1 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene STARR-seq mESC enhancer starr_47970 Neighboring gene G protein-coupled receptor associated sorting protein 1 Neighboring gene armadillo repeat containing, X-linked 5 Neighboring gene microRNA 7646 Neighboring gene RAB18, member RAS oncogene family pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
thymosin beta-15A
Names
thymosin beta-like protein 1
thymosin-like 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030106.3NP_084382.1  thymosin beta-15A

    See identical proteins and their annotated locations for NP_084382.1

    Status: VALIDATED

    Source sequence(s)
    AL671911
    Consensus CDS
    CCDS41130.1
    UniProtKB/TrEMBL
    Q9D2R9
    Related
    ENSMUSP00000073355.3, ENSMUST00000073674.3
    Conserved Domains (1) summary
    pfam01290
    Location:339
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134619416..134626010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528628.2XP_006528691.1  thymosin beta-15A isoform X1

    UniProtKB/TrEMBL
    A2AEH9
    Related
    ENSMUSP00000108779.2, ENSMUST00000113154.8
    Conserved Domains (1) summary
    pfam01290
    Location:3773
    Thymosin; Thymosin beta-4 family
  2. XM_006528629.2XP_006528692.1  thymosin beta-15A isoform X2

    See identical proteins and their annotated locations for XP_006528692.1

    UniProtKB/TrEMBL
    Q9D2R9
    Conserved Domains (1) summary
    pfam01290
    Location:339
    Thymosin; Thymosin beta-4 family