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Cyren cell cycle regulator of NHEJ [ Mus musculus (house mouse) ]

Gene ID: 78412, updated on 27-Nov-2024

Summary

Official Symbol
Cyrenprovided by MGI
Official Full Name
cell cycle regulator of NHEJprovided by MGI
Primary source
MGI:MGI:1925662
See related
Ensembl:ENSMUSG00000046806 AllianceGenome:MGI:1925662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mri; 3110062M04Rik
Summary
Enables damaged DNA binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; positive regulation of double-strand break repair via nonhomologous end joining; and protein localization to site of double-strand break. Part of DNA repair complex. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 19.4), subcutaneous fat pad adult (RPKM 12.4) and 26 other tissues See more
Orthologs
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Genomic context

See Cyren in Genome Data Viewer
Location:
6 B1; 6 15.18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34848706..34855024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34871771..34878065, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 46957 Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene STARR-positive B cell enhancer mm9_chr6:34860831-34861132 Neighboring gene stimulated by retinoic acid gene 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of DNA repair complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell cycle regulator of non-homologous end joining
Names
modulator of retrovirus infection homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135611.1NP_001129083.1  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_001129083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK042380, AK083365, BB611813
    Consensus CDS
    CCDS19997.1
    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Related
    ENSMUSP00000110659.3, ENSMUST00000115007.9
    Conserved Domains (1) summary
    pfam15325
    Location:55157
    MRI; Modulator of retrovirus infection
  2. NM_001347101.1NP_001334030.1  cell cycle regulator of non-homologous end joining isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' coding region, compared to variant 1. These differences result in a longer isoform (2), compared to isoform 1.
    Source sequence(s)
    AC153869
    Consensus CDS
    CCDS85030.1
    UniProtKB/Swiss-Prot
    Q8BHZ5
    Related
    ENSMUSP00000110658.2, ENSMUST00000115006.2
  3. NM_199145.2NP_954596.1  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_954596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK042380, BB611813
    Consensus CDS
    CCDS19997.1
    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Related
    ENSMUSP00000053349.5, ENSMUST00000055097.11
    Conserved Domains (1) summary
    pfam15325
    Location:55157
    MRI; Modulator of retrovirus infection

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34848706..34855024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255676.2XP_030111536.1  cell cycle regulator of non-homologous end joining isoform X1

    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Conserved Domains (1) summary
    pfam15325
    Location:55157
    MRI; Modulator of retrovirus infection