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Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 [ Mus musculus (house mouse) ]

Gene ID: 78244, updated on 27-Nov-2024

Summary

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Official Symbol
Dnajc21provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C21provided by MGI
Primary source
MGI:MGI:1925371
See related
Ensembl:ENSMUSG00000044224 AllianceGenome:MGI:1925371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930461P20Rik; 9930116P15Rik
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm. Is expressed in blastocyst; central nervous system; and genitourinary system. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 8.2), cortex adult (RPKM 5.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc21 in Genome Data Viewer
Location:
15 A1; 15 5.35 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10446849..10470685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10446763..10470568, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene alanine-glyoxylate aminotransferase 2 Neighboring gene predicted gene, 52213 Neighboring gene STARR-positive B cell enhancer ABC_E9414 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene tetratricopeptide repeat domain 23-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 21
Names
DnaJ (Hsp40) homolog, subfamily C, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030046.3 → NP_084322.2  dnaJ homolog subfamily C member 21

    Status: VALIDATED

    Source sequence(s)
    AC102101
    Consensus CDS
    CCDS49581.1
    UniProtKB/Swiss-Prot
    E9Q8D0, Q3USP3
    Related
    ENSMUSP00000116865.2, ENSMUST00000136591.8
    Conserved Domains (4) summary
    sd00020
    Location:316 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00226
    Location:3 → 66
    DnaJ; DnaJ domain
    pfam12171
    Location:314 → 339
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13892
    Location:181 → 243
    DBINO; DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10446849..10470685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316801.3 → XP_017172290.1  dnaJ homolog subfamily C member 21 isoform X1

    Conserved Domains (5) summary
    PTZ00121
    Location:167 → 455
    PTZ00121; MAEBL; Provisional
    COG5269
    Location:4 → 267
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    PRK10767
    Location:2 → 66
    PRK10767; chaperone protein DnaJ; Provisional
    sd00020
    Location:316 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:314 → 339
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  2. XM_036159635.1 → XP_036015528.1  dnaJ homolog subfamily C member 21 isoform X2

    Conserved Domains (4) summary
    PTZ00121
    Location:56 → 346
    PTZ00121; MAEBL; Provisional
    COG5269
    Location:23 → 142
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    sd00020
    Location:191 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:189 → 214
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. XM_036159634.1 → XP_036015527.1  dnaJ homolog subfamily C member 21 isoform X2

    Conserved Domains (4) summary
    PTZ00121
    Location:56 → 346
    PTZ00121; MAEBL; Provisional
    COG5269
    Location:23 → 142
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    sd00020
    Location:191 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:189 → 214
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q8D0.1 GenPept UniProtKB/Swiss-Prot:E9Q8D0

Gene LinkOut

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