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Ermn ermin, ERM-like protein [ Mus musculus (house mouse) ]

Gene ID: 77767, updated on 27-Nov-2024

Summary

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Official Symbol
Ermnprovided by MGI
Official Full Name
ermin, ERM-like proteinprovided by MGI
Primary source
MGI:MGI:1925017
See related
Ensembl:ENSMUSG00000026830 AllianceGenome:MGI:1925017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ermin; mKIAA1189; A330104H05Rik
Summary
Enables actin filament binding activity. Acts upstream of or within several processes, including actin filament organization; morphogenesis of a branching structure; and regulation of cell shape. Located in several cellular components, including filopodium; glial cell projection; and main axon. Orthologous to human ERMN (ermin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 9.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Ermn in Genome Data Viewer
Location:
2 C1.1; 2 32.99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (57874920..57942962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58045115..58052864, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial pseudogene Neighboring gene predicted gene, 25388 Neighboring gene STARR-seq mESC enhancer starr_04536 Neighboring gene STARR-seq mESC enhancer starr_04537 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57771733-57772033 Neighboring gene STARR-seq mESC enhancer starr_04538 Neighboring gene STARR-seq mESC enhancer starr_04539 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57882224-57882524 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_04540 Neighboring gene STARR-positive B cell enhancer ABC_E3374 Neighboring gene STARR-positive B cell enhancer ABC_E2036 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1589 Neighboring gene STARR-positive B cell enhancer ABC_E3375 Neighboring gene STARR-positive B cell enhancer ABC_E5917 Neighboring gene STARR-positive B cell enhancer ABC_E5918 Neighboring gene STARR-positive B cell enhancer ABC_E7817 Neighboring gene STARR-positive B cell enhancer ABC_E5919 Neighboring gene cytohesin 1 interacting protein Neighboring gene predicted gene 13546

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ermin is a p116(RIP) -interacting protein promoting oligodendroglial differentiation and myelin maintenance. Wang S, et al. Glia, 2020 Nov. PMID 32530539
  2. Juxtanodin in retinal pigment epithelial cells: Expression and biological activities in regulating cell morphology and actin cytoskeleton organization. Liang F, et al. J Comp Neurol, 2018 Feb 1. PMID 28815590
  3. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. Brockschnieder D, et al. J Neurosci, 2006 Jan 18. PMID 16421295, Free PMC Article
  4. Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. He D, et al. Nat Neurosci, 2016 May. PMID 26928066, Free PMC Article
  5. Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Garaffo G, et al. Front Endocrinol (Lausanne), 2013. PMID 24427155, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that the Juxtanodin expression in rat retinal pigment epithelial cells, and Juxtanodin functional roles in regulating actin cytoskeleton architecture and morphology.
    Title: Juxtanodin in retinal pigment epithelial cells: Expression and biological activities in regulating cell morphology and actin cytoskeleton organization.
  2. plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis
    Title: Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1189, MGC107206

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in morphogenesis of a branching structure IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within morphogenesis of a branching structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell projection organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell projection organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in internode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in internode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in internode region of axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in paranode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in paranode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in paranode region of axon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ermin
Names
JN
juxtanodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029972.4 → NP_084248.2  ermin

    See identical proteins and their annotated locations for NP_084248.2

    Status: VALIDATED

    Source sequence(s)
    AL928564
    Consensus CDS
    CCDS16047.1
    UniProtKB/Swiss-Prot
    Q3UVY3, Q5DTZ8, Q5EBJ4, Q8C5L8, Q9CTR3
    Related
    ENSMUSP00000088458.6, ENSMUST00000090940.6
    Conserved Domains (1) summary
    pfam00769
    Location:261 → 278
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    57874920..57942962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162717.1 → XP_036018610.1  ermin isoform X1

  2. XM_036162719.1 → XP_036018612.1  ermin isoform X2

  3. XM_036162718.1 → XP_036018611.1  ermin isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5EBJ4.1 GenPept UniProtKB/Swiss-Prot:Q5EBJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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