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st14b ST14 transmembrane serine protease matriptase b [ Danio rerio (zebrafish) ]

Gene ID: 777629, updated on 4-Jan-2025

Summary

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Official Symbol
st14bprovided by ZNC
Official Full Name
ST14 transmembrane serine protease matriptase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061103-613
See related
Ensembl:ENSDARG00000044655 AllianceGenome:ZFIN:ZDB-GENE-061103-613
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:152947
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within complement activation and proteolysis. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See st14b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (25275278..25295111, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (25239063..25258519, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45B Neighboring gene guanine nucleotide binding protein (G protein), gamma 8 Neighboring gene nuclear factor related to kappaB binding protein Neighboring gene uncharacterized LOC137488866 Neighboring gene odorant receptor, family 92, subfamily A, member 1 Neighboring gene odorant receptor, family 92, subfamily A, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. Ohler A, et al. Biol Chem, 2011 Jul. PMID 21657981
  2. Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Carney TJ, et al. Development, 2007 Oct. PMID 17728346
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within complement activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ST14 transmembrane serine protease matriptase b
Names
matriptase 1b
suppression of tumorigenicity 14 (colon carcinoma) b
suppression of tumorigenicity 14b
NP_001071205.1
XP_005161261.1
XP_009293607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077737.1 → NP_001071205.1  ST14 transmembrane serine protease matriptase b

    See identical proteins and their annotated locations for NP_001071205.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125837
    UniProtKB/TrEMBL
    A0JMD7
    Related
    ENSDARP00000082343.4, ENSDART00000087910.6
    Conserved Domains (5) summary
    smart00020
    Location:513 → 747
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:233 → 346
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:425 → 459
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:514 → 750
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:92 → 180
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    25275278..25295111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295332.4 → XP_009293607.1  ST14 transmembrane serine protease matriptase b isoform X1

    See identical proteins and their annotated locations for XP_009293607.1

    UniProtKB/TrEMBL
    A0A8M3AWU9, E9QD17
    Conserved Domains (5) summary
    smart00020
    Location:624 → 858
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:351 → 457
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:536 → 570
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:625 → 861
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:92 → 180
    SEA; SEA domain

  2. XM_005161204.5 → XP_005161261.1  ST14 transmembrane serine protease matriptase b isoform X1

    See identical proteins and their annotated locations for XP_005161261.1

    UniProtKB/TrEMBL
    A0A8M3AWU9, E9QD17
    Related
    ENSDARP00000119901.1, ENSDART00000147860.2
    Conserved Domains (5) summary
    smart00020
    Location:624 → 858
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:351 → 457
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:536 → 570
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:625 → 861
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:92 → 180
    SEA; SEA domain
Nucleotide Protein Strain
Heading Accession and Version

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