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zfyve28 zinc finger, FYVE domain containing 28 [ Danio rerio (zebrafish) ]

Gene ID: 777615, updated on 9-Dec-2024

Summary

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Official Symbol
zfyve28provided by ZNC
Official Full Name
zinc finger, FYVE domain containing 28provided by ZNC
Primary source
ZFIN:ZDB-GENE-061103-208
See related
Ensembl:ENSDARG00000060430 AllianceGenome:ZFIN:ZDB-GENE-061103-208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
id:ibd1374; zgc:152894
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane. Is expressed in axial chorda mesoderm; immature eye; and notochord. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See zfyve28 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43564882..43594837, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43574344..43604326, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:dkey-21a6.5 Neighboring gene si:dkey-84k15.7 Neighboring gene 5'-nucleotidase, cytosolic IAb Neighboring gene cilia and flagella associated protein 99 Neighboring gene rhotekin 2 Neighboring gene zinc finger protein 365

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown of Tmem234 in zebrafish results in proteinuria. Rodriguez PQ, et al. Am J Physiol Renal Physiol, 2015 Dec 1. PMID 26377798
  2. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. Du X, et al. FASEB J, 2018 Feb. PMID 29042450
  3. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lateral signaling target protein 2 homolog
Names
zinc finger FYVE domain-containing protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077723.1 → NP_001071191.1  lateral signaling target protein 2 homolog

    See identical proteins and their annotated locations for NP_001071191.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125831
    UniProtKB/Swiss-Prot
    A0JMD2
    Related
    ENSDARP00000116818.1, ENSDART00000139980.3
    Conserved Domains (1) summary
    cd15731
    Location:892 → 956
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    43564882..43594837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158876.5 → XP_005158933.1  lateral signaling target protein 2 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5E2
    Conserved Domains (1) summary
    cd15731
    Location:866 → 930
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JMD2.1 GenPept UniProtKB/Swiss-Prot:A0JMD2

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