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Mrps5 mitochondrial ribosomal protein S5 [ Mus musculus (house mouse) ]

Gene ID: 77721, updated on 27-Nov-2024

Summary

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Official Symbol
Mrps5provided by MGI
Official Full Name
mitochondrial ribosomal protein S5provided by MGI
Primary source
MGI:MGI:1924971
See related
Ensembl:ENSMUSG00000027374 AllianceGenome:MGI:1924971
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1620401I16Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS5 (mitochondrial ribosomal protein S5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.9), CNS E18 (RPKM 25.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrps5 in Genome Data Viewer
Location:
2 F1; 2 62.05 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127429346..127445906)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127587426..127603986)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14229 Neighboring gene zinc finger protein 661 Neighboring gene STARR-seq mESC enhancer starr_05627 Neighboring gene STARR-seq mESC enhancer starr_05628 Neighboring gene myelin and lymphocyte protein, T cell differentiation protein Neighboring gene predicted gene, 22889

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading. Juskeviciene R, et al. Int J Mol Sci, 2022 Apr 15. PMID 35457201, Free PMC Article
  2. Mitonuclear protein imbalance as a conserved longevity mechanism. Houtkooper RH, et al. Nature, 2013 May 23. PMID 23698443, Free PMC Article
  3. A defect in mitochondrial protein translation influences mitonuclear communication in the heart. Gao F, et al. Nat Commun, 2023 Mar 22. PMID 36949106, Free PMC Article
  4. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
    Title: Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS5m
Names
28S ribosomal protein S5, mitochondrial
MRP-S5
S5mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029963.2 → NP_084239.1  small ribosomal subunit protein uS5m

    Status: PROVISIONAL

    Source sequence(s)
    AB049941
    Consensus CDS
    CCDS16706.1
    UniProtKB/Swiss-Prot
    Q99N87
    UniProtKB/TrEMBL
    Q3U2U4
    Related
    ENSMUSP00000028852.7, ENSMUST00000028852.13
    Conserved Domains (3) summary
    TIGR01021
    Location:219 → 374
    rpsE_bact; ribosomal protein S5, bacterial/organelle type
    pfam00333
    Location:220 → 285
    Ribosomal_S5; Ribosomal protein S5, N-terminal domain
    pfam03719
    Location:299 → 367
    Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127429346..127445906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N87.1 GenPept UniProtKB/Swiss-Prot:Q99N87

Gene LinkOut

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