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Sphkap SPHK1 interactor, AKAP domain containing [ Mus musculus (house mouse) ]

Gene ID: 77629, updated on 27-Nov-2024

Summary

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Official Symbol
Sphkapprovided by MGI
Official Full Name
SPHK1 interactor, AKAP domain containingprovided by MGI
Primary source
MGI:MGI:1924879
See related
Ensembl:ENSMUSG00000026163 AllianceGenome:MGI:1924879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKIP; mKIAA1678; 4930544G21Rik; A930009L15Rik
Summary
Enables protein kinase A binding activity. Located in Z disc and mitochondrion. Is expressed in central nervous system; foot; heart; pancreas; and retina. Orthologous to human SPHKAP (SPHK1 interactor, AKAP domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 36.4), frontal lobe adult (RPKM 12.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Sphkap in Genome Data Viewer
Location:
1 C5; 1 42.73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (83233163..83385853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (83255442..83408411, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dynein assembly factor with WDR repeat domains 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene mitochondrial ribosome recycling factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_01496 Neighboring gene STARR-seq mESC enhancer starr_01497 Neighboring gene STARR-seq mESC enhancer starr_01498 Neighboring gene STARR-seq mESC enhancer starr_01499 Neighboring gene STARR-seq mESC enhancer starr_01500 Neighboring gene STARR-seq mESC enhancer starr_01501 Neighboring gene STARR-seq mESC enhancer starr_01502 Neighboring gene predicted gene, 24555 Neighboring gene predicted gene, 51636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion. Wang Y, et al. Sci Rep, 2017 Apr 10. PMID 28396589, Free PMC Article
  2. Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion. Liu Y, et al. FASEB J, 2019 May. PMID 30789757
  3. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Means CK, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084075, Free PMC Article
  4. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
  5. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of SKIP improves glucose tolerance through increasing not only insulin secretion but also GIP and GLP-1 secretions.
    Title: Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion.
  2. These results indicate that SKIP modulates GSIS by a pathway distinct from that of cAMP-, PDE- and sphingosine kinase-dependent pathways.
    Title: Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
A-kinase anchor protein SPHKAP
Names
SPHK1-interactor and AKAP domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356547.2 → NP_001343476.1  A-kinase anchor protein SPHKAP isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144
    UniProtKB/Swiss-Prot
    Q6NSW3, Q6PAM6, Q6PAP7, Q80TA7, Q80XT3, Q8BYQ9, Q8BZL6, Q8C1G7
    Conserved Domains (1) summary
    cl14906
    Location:1580 → 1680
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  2. NM_001405283.1 → NP_001392212.1  A-kinase anchor protein SPHKAP isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144

  3. NM_001405284.1 → NP_001392213.1  A-kinase anchor protein SPHKAP isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144

  4. NM_001405285.1 → NP_001392214.1  A-kinase anchor protein SPHKAP isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144

  5. NM_001405286.1 → NP_001392215.1  A-kinase anchor protein SPHKAP isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144

  6. NM_001405287.1 → NP_001392216.1  A-kinase anchor protein SPHKAP isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144

  7. NM_172430.5 → NP_766018.3  A-kinase anchor protein SPHKAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138359, AC154144
    Consensus CDS
    CCDS48298.1
    UniProtKB/Swiss-Prot
    Q6NSW3, Q6PAM6, Q6PAP7, Q80TA7, Q80XT3, Q8BYQ9, Q8BZL6, Q8C1G7
    UniProtKB/TrEMBL
    E9PUC4
    Related
    ENSMUSP00000124872.2, ENSMUST00000160953.8
    Conserved Domains (1) summary
    cl14906
    Location:1555 → 1655
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    83233163..83385853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSW3.2 GenPept UniProtKB/Swiss-Prot:Q6NSW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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